UCLA Neuroscience Program Ph.D. Admissions Neuroscience Faculty UCLA and Beyond  



Tyrone Cannon
Neuroscience and Genetics of Schizophrenia and Bipolar Disorder

Email Address:  cannon@psych.ucla.edu
Home Page: http://www.cannonlab.psych.ucla.edu

Office Address:
5586 Franz Hall


Phone Numbers:
310-206-8765 Office


Selected Publications:

Murray, G. K. Veijola, J. Moilanen, K. Miettunen, J. Glahn, D. C. Cannon, T. D. Jones, P. B. Isohanni, M. Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort study. J Child Psychol Psychiatry. 2006; 47(1): 25-9.
Cannon, T. D. Thompson, P. M. van Erp, T. G. Huttunen, M. Lonnqvist, J. Kaprio, J. Toga, A. W. Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: methods and applications to schizophrenia. Neuroinformatics. 2006; 4(1): 5-19.
Niendam, T. A. Bearden, C. E. Johnson, J. K. McKinley, M. Loewy, R. O'Brien, M. Nuechterlein, K. H. Green, M. F. Cannon, T. D. Neurocognitive performance and functional disability in the psychosis prodrome. Schizophr Res. 2006; 84(1): 100-11.
Hennah, W. Tuulio-Henriksson, A. Paunio, T. Ekelund, J. Varilo, T. Partonen, T. Cannon, T. D. Lonnqvist, J. Peltonen, L. A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia. Mol Psychiatry. 2005; 10(12): 1097-103.
Cannon, T. D. Hennah, W. van Erp, T. G. Thompson, P. M. Lonnqvist, J. Huttunen, M. Gasperoni, T. Tuulio-Henriksson, A. Pirkola, T. Toga, A. W. Kaprio, J. Mazziotta, J. Peltonen, L. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry. 2005; 62(11): 1205-13.
Cannon, T. D. Glahn, D. C. Kim, J. Van Erp, T. G. Karlsgodt, K. Cohen, M. S. Nuechterlein, K. H. Bava, S. Shirinyan, D. Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry. 2005; 62(10): 1071-80.
Hirvonen, J. van Erp, T. G. Huttunen, J. Aalto, S. Nagren, K. Huttunen, M. Lonnqvist, J. Kaprio, J. Hietala, J. Cannon, T. D. Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia. Arch Gen Psychiatry. 2005; 62(4): 371-8.
Kieseppa, T. Tuulio-Henriksson, A. Haukka, J. Van Erp, T. Glahn, D. Cannon, T. D. Partonen, T. Kaprio, J. Lonnqvist, J. Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed. Psychol Med. 2005; 35(2): 205-15.
Cannon, T. D. The inheritance of intermediate phenotypes for schizophrenia. Curr Opin Psychiatry. 2005; 18(2): 135-40.
Meyer, S. E. Bearden, C. E. Lux, S. R. Gordon, J. L. Johnson, J. K. O'Brien, M. P. Niendam, T. A. Loewy, R. L. Ventura, J. Cannon, T. D. The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV. J Child Adolesc Psychopharmacol. 2005; 15(3): 434-51.
van Erp, T. G. Saleh, P. A. Huttunen, M. Lonnqvist, J. Kaprio, J. Salonen, O. Valanne, L. Poutanen, V. P. Standertskjold-Nordenstam, C. G. Cannon, T. D. Hippocampal volumes in schizophrenic twins. Arch Gen Psychiatry. 2004; 61(4): 346-53.
Thompson, P. M. Hayashi, K. M. Sowell, E. R. Gogtay, N. Giedd, J. N. Rapoport, J. L. de Zubicaray, G. I. Janke, A. L. Rose, S. E. Semple, J. Doddrell, D. M. Wang, Y. van Erp, T. G. Cannon, T. D. Toga, A. W. Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia. Neuroimage. 2004; 23 Suppl 1: S2-18.
Bearden, C. E. van Erp, T. G. Monterosso, J. R. Simon, T. J. Glahn, D. C. Saleh, P. A. Hill, N. M. McDonald-McGinn, D. M. Zackai, E. Emanuel, B. S. Cannon, T. D. Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms. Neurocase. 2004; 10(3): 198-206.
Schnack, H. G. van Haren, N. E. Hulshoff Pol, H. E. Picchioni, M. Weisbrod, M. Sauer, H. Cannon, T. Huttunen, M. Murray, R. Kahn, R. S. Reliability of brain volumes from multicenter MRI acquisition: a calibration study. Hum Brain Mapp. 2004; 22(4): 312-20.
Niendam, T. A. Bearden, C. E. Rosso, I. M. Sanchez, L. E. Hadley, T. Nuechterlein, K. H. Cannon, T. D. A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Am J Psychiatry. 2003; 160(11): 2060-2.
Cannon, T. D. van Erp, T. G. Bearden, C. E. Loewy, R. Thompson, P. Toga, A. W. Huttunen, M. O. Keshavan, M. S. Seidman, L. J. Tsuang, M. T. Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions. Schizophr Bull. 2003; 29(4): 653-69.
Miller, T. J. McGlashan, T. H. Rosen, J. L. Cadenhead, K. Cannon, T. Ventura, J. McFarlane, W. Perkins, D. O. Pearlson, G. D. Woods, S. W. Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull. 2003; 29(4): 703-15.
Carter, J. W. Schulsinger, F. Parnas, J. Cannon, T. Mednick, S. A. A multivariate prediction model of schizophrenia. Schizophr Bull. 2002; 28(4): 649-82.
Narr, K. L. van Erp, T. G. Cannon, T. D. Woods, R. P. Thompson, P. M. Jang, S. Blanton, R. Poutanen, V. P. Huttunen, M. Lonnqvist, J. Standerksjold-Nordenstam, C. G. Kaprio, J. Mazziotta, J. C. Toga, A. W. A twin study of genetic contributions to hippocampal morphology in schizophrenia. Neurobiol Dis. 2002; 11(1): 83-95.
Cannon, T. D. Huttunen, M. O. Dahlstrom, M. Larmo, I. Rasanen, P. Juriloo, A. Antipsychotic drug treatment in the prodromal phase of schizophrenia. Am J Psychiatry. 2002; 159(7): 1230-2.
Van Erp, T. G. Saleh, P. A. Rosso, I. M. Huttunen, M. Lonnqvist, J. Pirkola, T. Salonen, O. Valanne, L. Poutanen, V. P. Standertskjold-Nordenstam, C. G. Cannon, T. D. Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. Am J Psychiatry. 2002; 159(9): 1514-20.
Cannon, T. D. van Erp, T. G. Rosso, I. M. Huttunen, M. Lonnqvist, J. Pirkola, T. Salonen, O. Valanne, L. Poutanen, V. P. Standertskjold-Nordenstam, C. G. Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatry. 2002; 59(1): 35-41.
Cannon, T. D. Rosso, I. M. Levels of analysis in etiological research on schizophrenia. Dev Psychopathol. 2002; 14(3): 653-66.
Glahn, D. C. Kim, J. Cohen, M. S. Poutanen, V. P. Therman, S. Bava, S. Van Erp, T. G. Manninen, M. Huttunen, M. Lonnqvist, J. Standertskjold-Nordenstam, C. G. Cannon, T. D. Maintenance and manipulation in spatial working memory: dissociations in the prefrontal cortex. Neuroimage. 2002; 17(1): 201-13.
Thompson, P. Cannon, T. D. Toga, A. W. Mapping genetic influences on human brain structure. Ann Med. 2002; 34(7-8): 523-36.
Schiffman, J. LaBrie, J. Carter, J. Cannon, T. Schulsinger, F. Parnas, J. Mednick, S. Perception of parent-child relationships in high-risk families, and adult schizophrenia outcome of offspring. J Psychiatr Res. 2002; 36(1): 41-7.
Salokangas, R. K. Cannon, T. Van Erp, T. Ilonen, T. Taiminen, T. Karlsson, H. Lauerma, H. Leinonen, K. M. Wallenius, E. Kaljonen, A. Syvalahti, E. Vilkman, H. Alanen, A. Hietala, J. Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project. Br J Psychiatry Suppl. 2002; 43: s58-65.
Kieseppa, T. van Erp, T. G. Haukka, J. Partonen, T. Cannon, T. D. Poutanen, V. P. Kapri, J. Lonnqvist, J. The volumetric findings in MRI brain study of bipolar twins and their healthy co-twins. Bipolar Disord. 2002; 4 Suppl 1: 29-30.
Mazziotta, J. Toga, A. Evans, A. Fox, P. Lancaster, J. Zilles, K. Woods, R. Paus, T. Simpson, G. Pike, B. Holmes, C. Collins, L. Thompson, P. MacDonald, D. Iacoboni, M. Schormann, T. Amunts, K. Palomero-Gallagher, N. Geyer, S. Parsons, L. Narr, K. Kabani, N. Le Goualher, G. Feidler, J. Smith, K. Boomsma, D. Hulshoff Pol, H. Cannon, T. Kawashima, R. Mazoyer, B. A four-dimensional probabilistic atlas of the human brain. J Am Med Inform Assoc. 2001; 8(5): 401-30.
Thompson, P. M. Cannon, T. D. Narr, K. L. van Erp, T. Poutanen, V. P. Huttunen, M. Lonnqvist, J. Standertskjold-Nordenstam, C. G. Kaprio, J. Khaledy, M. Dail, R. Zoumalan, C. I. Toga, A. W. Genetic influences on brain structure. Nat Neurosci. 2001; 4(12): 1253-8.
Bearden, C. E. Woodin, M. F. Wang, P. P. Moss, E. McDonald-McGinn, D. Zackai, E. Emannuel, B. Cannon, T. D. The neurocognitive phenotype of the 22q11.2 deletion syndrome: selective deficit in visual-spatial memory. J Clin Exp Neuropsychol. 2001; 23(4): 447-64.
Bearden, C. E. Hoffman, K. M. Cannon, T. D. The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord. 2001; 3(3): 106-50; discussion 151-3.
Bearden, C. E. Rosso, I. M. Hollister, J. M. Sanchez, L. E. Hadley, T. Cannon, T. D. A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia. Schizophr Bull. 2000; 26(2): 395-410.
Cannon, T. D. Rosso, I. M. Hollister, J. M. Bearden, C. E. Sanchez, L. E. Hadley, T. A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia. Schizophr Bull. 2000; 26(2): 351-66.
Cannon, T. D. Bearden, C. E. Hollister, J. M. Rosso, I. M. Sanchez, L. E. Hadley, T. Childhood cognitive functioning in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr Bull. 2000; 26(2): 379-93.
Rosso, I. M. Bearden, C. E. Hollister, J. M. Gasperoni, T. L. Sanchez, L. E. Hadley, T. Cannon, T. D. Childhood neuromotor dysfunction in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr Bull. 2000; 26(2): 367-78.
Rosso, I. M. Cannon, T. D. Huttunen, T. Huttunen, M. O. Lonnqvist, J. Gasperoni, T. L. Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. Am J Psychiatry. 2000; 157(5): 801-7.
Cannon, T. D. Huttunen, M. O. Lonnqvist, J. Tuulio-Henriksson, A. Pirkola, T. Glahn, D. Finkelstein, J. Hietanen, M. Kaprio, J. Koskenvuo, M. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet. 2000; 67(2): 369-82.
Cannon, T. D. Rosso, I. M. Bearden, C. E. Sanchez, L. E. Hadley, T. A prospective cohort study of neurodevelopmental processes in the genesis and epigenesis of schizophrenia. Dev Psychopathol. 1999; 11(3): 467-85.
Carter, J. W. Parnas, J. Cannon, T. D. Schulsinger, F. Mednick, S. A. MMPI variables predictive of schizophrenia in the Copenhagen High-Risk Project: a 25-year follow-up. Acta Psychiatr Scand. 1999; 99(6): 432-40.
Cicchetti, D. Cannon, T. D. Neurodevelopmental processes in the ontogenesis and epigenesis of psychopathology. Dev Psychopathol. 1999; 11(3): 375-93.
Joo, E. J. Lee, J. H. Cannon, T. D. Price, R. A. Possible association between schizophrenia and a CAG repeat polymorphism in the spinocerebellar ataxia type 1 (SCA1) gene on human chromosome 6p23. Psychiatr Genet. 1999; 9(1): 7-11.
Gur, R. E. Cowell, P. Turetsky, B. I. Gallacher, F. Cannon, T. Bilker, W. Gur, R. C. A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Arch Gen Psychiatry. 1998; 55(2): 145-52.
Cannon, T. D. van Erp, T. G. Huttunen, M. Lonnqvist, J. Salonen, O. Valanne, L. Poutanen, V. P. Standertskjold-Nordenstam, C. G. Gur, R. E. Yan, M. Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatry. 1998; 55(12): 1084-91.
Olin, S. C. Mednick, S. A. Cannon, T. Jacobsen, B. Parnas, J. Schulsinger, F. Schulsinger, H. School teacher ratings predictive of psychiatric outcome 25 years later. Br J Psychiatry Suppl. 1998; 172(33): 7-13.
Cannon, T. D. Kaprio, J. Lonnqvist, J. Huttunen, M. Koskenvuo, M. The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch Gen Psychiatry. 1998; 55(1): 67-74.
Finkelstein, J. R. Cannon, T. D. Gur, R. E. Gur, R. C. Moberg, P. Attentional dysfunctions in neuroleptic-naive and neuroleptic-withdrawn schizophrenic patients and their siblings. J Abnorm Psychol. 1997; 106(2): 203-12.
Olin, S. S. Raine, A. Cannon, T. D. Parnas, J. Schulsinger, F. Mednick, S. A. Childhood behavior precursors of schizotypal personality disorder. Schizophr Bull. 1997; 23(1): 93-103.
Higgins, J. Gore, R. Gutkind, D. Mednick, S. A. Parnas, J. Schulsinger, F. Cannon, T. D. Effects of child-rearing by schizophrenic mothers: a 25-year follow-up. Acta Psychiatr Scand. 1997; 96(5): 402-4.
Cannon, T. D. Abnormalities of brain structure and function in schizophrenia: implications for aetiology and pathophysiology. Ann Med. 1996; 28(6): 533-9.
Szymanski, S. R. Cannon, T. D. Gallacher, F. Erwin, R. J. Gur, R. E. Course of treatment response in first-episode and chronic schizophrenia. Am J Psychiatry. 1996; 153(4): 519-25.
Tyrka, A. R. Cannon, T. D. Haslam, N. Mednick, S. A. Schulsinger, F. Schulsinger, H. Parnas, J. The latent structure of schizotypy: I. Premorbid indicators of a taxon of individuals at risk for schizophrenia-spectrum disorders. J Abnorm Psychol. 1995; 104(1): 173-83.
Gur, R. E. Mozley, P. D. Shtasel, D. L. Cannon, T. D. Gallacher, F. Turetsky, B. Grossman, R. Gur, R. C. Clinical subtypes of schizophrenia: differences in brain and CSF volume. Am J Psychiatry. 1994; 151(3): 343-50.
Cannon, T. D. Mednick, S. A. Parnas, J. Schulsinger, F. Praestholm, J. Vestergaard, A. Developmental brain abnormalities in the offspring of schizophrenic mothers. II. Structural brain characteristics of schizophrenia and schizotypal personality disorder. Arch Gen Psychiatry. 1994; 51(12): 955-62.
Hollister, J. M. Mednick, S. A. Brennan, P. Cannon, T. D. Impaired autonomic nervous system-habituation in those at genetic risk for schizophrenia. Arch Gen Psychiatry. 1994; 51(7): 552-8.
Cannon, T. D. Zorrilla, L. E. Shtasel, D. Gur, R. E. Gur, R. C. Marco, E. J. Moberg, P. Price, R. A. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch Gen Psychiatry. 1994; 51(8): 651-61.
Cannon, T. D. Marco, E. Structural brain abnormalities as indicators of vulnerability to schizophrenia. Schizophr Bull. 1994; 20(1): 89-102.
Cannon, T. D. Mednick, S. A. Parnas, J. Schulsinger, F. Praestholm, J. Vestergaard, A. Developmental brain abnormalities in the offspring of schizophrenic mothers. I. Contributions of genetic and perinatal factors. Arch Gen Psychiatry. 1993; 50(7): 551-64.
Parnas, J. Cannon, T. D. Jacobsen, B. Schulsinger, H. Schulsinger, F. Mednick, S. A. Lifetime DSM-III-R diagnostic outcomes in the offspring of schizophrenic mothers. Results from the Copenhagen High-Risk Study. Arch Gen Psychiatry. 1993; 50(9): 707-14.
Cannon, T. D. Mednick, S. A. The schizophrenia high-risk project in Copenhagen: three decades of progress. Acta Psychiatr Scand Suppl. 1993; 370: 33-47.
Shtasel, D. L. Gur, R. E. Gallacher, F. Heimberg, C. Cannon, T. Gur, R. C. Phenomenology and functioning in first-episode schizophrenia. Schizophr Bull. 1992; 18(3): 449-62.
Cannon, T. D. Raine, A. Herman, T. M. Mednick, S. A. Schulsinger, F. Moore, M. Third ventricle enlargement and lower heart rate levels in a high-risk sample. Psychophysiology. 1992; 29(3): 294-301.
Erel, O. Cannon, T. D. Hollister, J. M. Mednick, S. A. Parnas, J. Ventricular enlargement and premorbid deficits in school-occupational attainment in a high risk sample. Schizophr Res. 1991; 4(1): 49-52.
Cannon, T. D. Mednick, S. A. Parnas, J. Antecedents of predominantly negative- and predominantly positive-symptom schizophrenia in a high-risk population. Arch Gen Psychiatry. 1990; 47(7): 622-32.
Lyon, M. Barr, C. E. Cannon, T. D. Mednick, S. A. Shore, D. Fetal neural development and schizophrenia. Schizophr Bull. 1989; 15(1): 149-61.
Cannon, T. D. Mednick, S. A. Parnas, J. Genetic and perinatal determinants of structural brain deficits in schizophrenia. Arch Gen Psychiatry. 1989; 46(10): 883-9.
Cannon, T. D. Fuhrmann, M. Mednick, S. A. Machon, R. A. Parnas, J. Schulsinger, F. Third ventricle enlargement and reduced electrodermal responsiveness. Psychophysiology. 1988; 25(2): 153-6.
Ahveninen, J. Jaaskelainen, I. P. Osipova, D. Huttunen, M. O. Ilmoniemi, R. J. Kaprio, J. Lonnqvist, J. Manninen, M. Pakarinen, S. Therman, S. Naatanen, R. Cannon, T. D. Inherited Auditory-Cortical Dysfunction in Twin Pairs Discordant for Schizophrenia. Biol Psychiatry. 2006; .
O'Brien, M. P. Gordon, J. L. Bearden, C. E. Lopez, S. R. Kopelowicz, A. Cannon, T. D. Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosis. Schizophr Res. 2006; 81(2-3): 269-75.
Hirvonen, J. van Erp, T. G. Huttunen, J. Nagren, K. Huttunen, M. Aalto, S. Lonnqvist, J. Kaprio, J. Cannon, T. D. Hietala, J. Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia. Psychiatry Res. 2006; 146(1): 13-20.
Murray, G. K. Jones, P. B. Moilanen, K. Veijola, J. Miettunen, J. Cannon, T. D. Isohanni, M. Infant motor development and adult cognitive functions in schizophrenia. Schizophr Res. 2006; 81(1): 65-74.
Pirkola, T. Tuulio-Henriksson, A. Glahn, D. Kieseppa, T. Haukka, J. Kaprio, J. Lonnqvist, J. Cannon, T. D. Spatial working memory function in twins with schizophrenia and bipolar disorder. Biol Psychiatry. 2005; 58(12): 930-6.
Li, W. Cui, Y. Kushner, S. A. Brown, R. A. Jentsch, J. D. Frankland, P. W. Cannon, T. D. Silva, A. J. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol. 2005; 15(21): 1961-7.
Cannon, T. D. Clinical and genetic high-risk strategies in understanding vulnerability to psychosis. Schizophr Res. 2005; 79(1): 35-44.
Loewy, R. L. Bearden, C. E. Johnson, J. K. Raine, A. Cannon, T. D. The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromes. Schizophr Res. 2005; 79(1): 117-25.
Karlsgodt, K. H. Shirinyan, D. van Erp, T. G. Cohen, M. S. Cannon, T. D. Hippocampal activations during encoding and retrieval in a verbal working memory paradigm. Neuroimage. 2005; 25(4): 1224-31.
Paunio, T. Tuulio-Henriksson, A. Hiekkalinna, T. Perola, M. Varilo, T. Partonen, T. Cannon, T. D. Lonnqvist, J. Peltonen, L. Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q. Hum Mol Genet. 2004; 13(16): 1693-702.
Kim, J. Glahn, D. C. Nuechterlein, K. H. Cannon, T. D. Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory. Schizophr Res. 2004; 68(2-3): 173-87.
Johnson, J. K. Tuulio-Henriksson, A. Pirkola, T. Huttunen, M. O. Lonnqvist, J. Kaprio, J. Cannon, T. D. Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?. Biol Psychiatry. 2003; 54(11): 1200-4.
Kieseppa, T. van Erp, T. G. Haukka, J. Partonen, T. Cannon, T. D. Poutanen, V. P. Kaprio, J. Lonnqvist, J. Reduced left hemispheric white matter volume in twins with bipolar I disorder. Biol Psychiatry. 2003; 54(9): 896-905.
Hietala, J. Cannon, T. D. van Erp, T. G. Syvalahti, E. Vilkman, H. Laakso, A. Vahlberg, T. Alakare, B. Rakkolainen, V. Salokangas, R. K. Regional brain morphology and duration of illness in never-medicated first-episode patients with schizophrenia. Schizophr Res. 2003; 64(1): 79-81.
Tuulio-Henriksson, A. Arajarvi, R. Partonen, T. Haukka, J. Varilo, T. Schreck, M. Cannon, T. Lonnqvist, J. Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients. Biol Psychiatry. 2003; 54(6): 623-8.
Glahn, D. C. Therman, S. Manninen, M. Huttunen, M. Kaprio, J. Lonnqvist, J. Cannon, T. D. Spatial working memory as an endophenotype for schizophrenia. Biol Psychiatry. 2003; 53(7): 624-6.
Gasperoni, T. L. Ekelund, J. Huttunen, M. Palmer, C. G. Tuulio-Henriksson, A. Lonnqvist, J. Kaprio, J. Peltonen, L. Cannon, T. D. Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003; 116(1): 8-16.
Tuulio-Henriksson, A. Haukka, J. Partonen, T. Varilo, T. Paunio, T. Ekelund, J. Cannon, T. D. Meyer, J. M. Lonnqvist, J. Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia. Am J Med Genet. 2002; 114(5): 483-90.
Narr, K. L. Cannon, T. D. Woods, R. P. Thompson, P. M. Kim, S. Asunction, D. van Erp, T. G. Poutanen, V. P. Huttunen, M. Lonnqvist, J. Standerksjold-Nordenstam, C. G. Kaprio, J. Mazziotta, J. C. Toga, A. W. Genetic contributions to altered callosal morphology in schizophrenia. J Neurosci. 2002; 22(9): 3720-9.
Cannon, T. D. Thompson, P. M. van Erp, T. G. Toga, A. W. Poutanen, V. P. Huttunen, M. Lonnqvist, J. Standerskjold-Nordenstam, C. G. Narr, K. L. Khaledy, M. Zoumalan, C. I. Dail, R. Kaprio, J. Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia. Proc Natl Acad Sci U S A. 2002; 99(5): 3228-33.
Cannon, T. D. van Erp, T. G. Glahn, D. C. Elucidating continuities and discontinuities between schizotypy and schizophrenia in the nervous system. Schizophr Res. 2002; 54(1-2): 151-6.
Mazziotta, J. Toga, A. Evans, A. Fox, P. Lancaster, J. Zilles, K. Woods, R. Paus, T. Simpson, G. Pike, B. Holmes, C. Collins, L. Thompson, P. MacDonald, D. Iacoboni, M. Schormann, T. Amunts, K. Palomero-Gallagher, N. Geyer, S. Parsons, L. Narr, K. Kabani, N. Le Goualher, G. Boomsma, D. Cannon, T. Kawashima, R. Mazoyer, B. A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). Philos Trans R Soc Lond B Biol Sci. 2001; 356(1412): 1293-322.
Cannon, T. D. Gasperoni, T. L. van Erp, T. G. Rosso, I. M. Quantitative neural indicators of liability to schizophrenia: implications for molecular genetic studies. Am J Med Genet. 2001; 105(1): 16-9.
Turetsky, B. I. Cannon, T. D. Gur, R. E. P300 subcomponent abnormalities in schizophrenia: III. Deficits In unaffected siblings of schizophrenic probands. Biol Psychiatry. 2000; 47(5): 380-90.
Glahn, D. C. Cannon, T. D. Gur, R. E. Ragland, J. D. Gur, R. C. Working memory constrains abstraction in schizophrenia. Biol Psychiatry. 2000; 47(1): 34-42.
Zorrilla, E. P. Cannon, T. D. Kessler, J. Gur, R. E. Leukocyte differentials predict short-term clinical outcome following antipsychotic treatment in schizophrenia. Biol Psychiatry. 1998; 43(12): 887-96.
Zorrilla, L. T. Cannon, T. D. Kronenberg, S. Mednick, S. A. Schulsinger, F. Parnas, J. Praestholm, J. Vestergaard, A. Structural brain abnormalities in schizophrenia: a family study. Biol Psychiatry. 1997; 42(12): 1080-6.
Arnold, S. E. Joo, E. Martinoli, M. G. Roy, N. Trojanowski, J. Q. Gur, R. E. Cannon, T. Price, R. A. Apolipoprotein E genotype in schizophrenia: frequency, age of onset, and neuropathologic features. Neuroreport. 1997; 8(6): 1523-6.
Zorrilla, L. T. Aguirre, G. K. Zarahn, E. Cannon, T. D. D'Esposito, M. Activation of the prefrontal cortex during judgments of recency: a functional MRI study. Neuroreport. 1996; 7(15-17): 2803-6.
Zorrilla, E. P. Cannon, T. D. Gur, R. E. Kessler, J. Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: markers of vulnerability or disease?. Biol Psychiatry. 1996; 40(9): 825-33.
Research Interest:

Dr. Cannon's research aims to discover the causes of schizophrenia and bipolar disorder and to develop effective treatment and prevention strategies based on an understanding of the genetic and neural mechanisms that give rise to these disorders. Dr. Cannon's studies have focused on elucidating the genetic and non-genetic factors that influence susceptibility to schizophrenia and bipolar disorder and delineating their effects on brain structure and functioning across development, with a particular emphasis on gestational (pre- and perinatal) and adolescent periods of brain development. A hallmark of his work is the integration of molecular biological and neuroimaging approaches in unique populations such as twins discordant for schizophrenia and bipolar disorder and selected members of large prospectively evaluated birth cohorts who have developed one of these conditions in adulthood. Dr. Cannon has established a clinical research center for early detection and prevention of major mental illness in at risk youth based in the UCLA Neuropsychiatric Institute. In that project he and his colleagues are ascertaining individuals who are at risk for imminent onset of psychosis and following them in longitudinal neuroimaging studies aimed at identifying the neural changes that occur proximally to onset of psychosis.