UCLA Neuroscience Program Ph.D. Admissions Neuroscience Faculty UCLA and Beyond  



Karen Gylys
Synapse Loss in Alzheimer's Disease

Email Address:  kgylys@sonnet.ucla.edu

Work Address:
Factor Building


Phone Numbers:
310 794-5472 laboratory
310-206-3840 Office


Selected Publications:

Gylys Karen H., Fein Jeffrey A., Yang Fusheng, Miller Carol A., Cole Gregory M. Increased Cholesterol in Amyloid beta-positive Nerve terminals from Alzheimers Disease Cortex. Neurobiology of Aging ; in press: .
Gylys, KH Fein, JA Yang, F Wiley, DJ Miller, CA Cole, GM Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence.. The American journal of pathology. . 2004; 165(5): 1809-17.
Gylys, Karen H., Fein, Jeffrey A, Yang, F, and Cole, Gregory M. Enrichment of Pre- and Post-synaptic Markers by Size-Based Gating Analysis of Synaptosome Preparations from Rat and Human Cortex. Cytometry, Part A 2004; 60A: 90-96.
Gylys KH, Fein JA, Tan AM, Cole GM Apolipoprotein E Enhances Uptake of Soluble but not Aggregated Amyloid-beta Protein into Synaptic Terminals. Journal of Neurochemistry 2003; 84(6): 1442-51.
Gylys, Karen H., Fein, Jeffrey A and Cole, Gregory M. Flow cytometry analysis of a crude synaptosomal fraction (P-2) from rat brain. J. Neurosci. Res. 2000; 61: 186-192.
Research Interest:

My lab is focused on understanding early changes in Alzheimer's disease brain, specifically the mechanisms by which synapses degenerate. We study postmortem Alzheimer's tissue and transgenic mouse models of this disease in an effort to identify the earliest pathways of damage and loss, when there may still be opportunity for reversal