McKay LC,
Janczewski WA,
Feldman JL Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons.
Nature Neuroscience.
2005;
8(9):
1142-1144.
Download
Saywell, SA Feldman, JL Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA..
The Journal of physiology. .
2004;
554(Pt 3):
879-89.
Download
Shao XM, Ge Q, Feldman JL Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat..
J Physiol
2003;
545(Pt 2):
543-53.
Mellen, NM Janczewski, WA Bocchiaro, CM Feldman, JL Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation..
Neuron. .
2003;
37(5):
821-6.
Download
Feldman, JL, McCrimmon DR Neural Control of Breathing.
Fundamental Neuroscience
2002;
Chapter 37:
.
Chamberlin, NL Bocchiaro, CM Greene, RW Feldman, JL Nicotinic excitation of rat hypoglossal motoneurons..
Neuroscience. .
2002;
115(3):
861-70.
Janczewski, WA Onimaru, H Homma, I Feldman, JL Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat..
The Journal of physiology. .
2002;
545(Pt 3):
1017-26.
Alheid, GF Gray, PA Jiang, MC Feldman, JL McCrimmon, DR Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat..
Journal of neurocytology. .
2002;
31(8-9):
693-717.
Shao XM, Feldman JL Pharmacology of nicotinic receptors in preBotzinger complex that mediate modulation of respiratory pattern..
J Neurophysiol
2002;
88(4):
1851-8.
Del Negro, CA Morgado-Valle, C Feldman, JL Respiratory rhythm: an emergent network property?.
Neuron. .
2002;
34(5):
821-30.
Download
Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL Normal breathing requires preBotzinger Complex neurokinin-1 receptor expressing neurons.
Nature Neuroscience
2001;
4(9):
927-930.
Download
Lai J, Shao XM, Pan RW, Dy E, Huang CH, Feldman JL RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Botzinger complex..
Am J Physiol Lung Cell Mol Physiol
2001;
281(6):
L1420-4.
Rekling, JC Funk, GD Bayliss, DA Dong, XW Feldman, JL Synaptic control of motoneuronal excitability..
Physiological reviews. .
2000;
80(2):
767-852.
Download
Gray, PA, Rekling, JC, Bocchiaro, CM, Feldman, JL Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex.
Science.
1999;
286:
1566-1568.
Download
Rekling, JC, Feldman, JL PreBotzinger Complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation.
Annual Review of Physiology.
1998;
60:
385-405.
Download
Smith JC, Ellenberger, HH, Ballanyi, K, Richter, DW, Feldman, JL Pre-botzinger complex: A brain region that may generate respiratory rhythm in mammals.
Science
1991;
254:
726-729.
Download
Janczewski, WA
Feldman, JL Distinct rhythm generators for inspiration and expiration in the juvenile rat.
J. Physiol..
2006;
570:
407-420.
Download
|
All meaningful actions of the brain result from the orchestrated activity of many neurons. A central problem confronting neuroscientists is to understand how molecular, synaptic, and cellular properties of individual neurons in densely interconnected networks result in behaviors ranging from hitting a baseball, playing the piano, reading or writing a book, taking an exam, regulating blood pressure or reproduction, or doing research.
We have developed a model system that enables us to perform unique studies that directly address this problem. We investigate the neural basis for respiration in the isolated neonate rat brainstem, a preparation that offers simultaneous access to cellular, synaptic and network properties. In this preparation, the circuitry mediating respiration has been localized in a discrete region of brainstem, which can be isolated in a 300 m m thick slice. Using the slice, sophisticated techniques are used to characterize the cellular and synaptic properties of neurons involved in respiration, while at the same time characterizing their interactions at the network level, and recording motor output. Exploiting this preparation, we intend to understand how homeostatically regulated breathing movements occur, and in course, principles of integrative organization in the nervous system.
We use whole-cell patch-clamp recording techniques to determine cellular and synaptic properties, including the pharmacology of identified synaptic interactions. We are presently testing our hypothesis that pacemaker neurons underlie the generation of respiratory rhythm. We have several projects looking at general mechanisms underlying the control of neuronal excitability (in functionally identified cells). In particular, we are interested in the interaction among amino acid, amine and peptide neurotransmitters. We have initiated a major program in molecular neurobiology to determine the interesting and unique molecules associated with identified cells in this network; presently, we are developing RT-PCR and mRNA differential display for this purpose. We are also interested in modeling, for which we have excellent computer facilities.
|
|
