Rahimi F, Murakami K, Summers JL, Chen C-HB, and Bitan G. RNA Aptamers Generated against Oligomeric Aβ40 Recognize Common Amyloid Aptatopes with Low Specificity but High Sensitivity.
PLoS ONE.
2009;
4(11):
doi:10.1371/journal.pone.0007694.
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Li H, Rahimi F, Sinha S, Maiti P, Murakami K, and Bitan G. Amyloids and Protein Aggregation—analytical methods.
Encyclopedia Anal. Chem.
2009;
Published online, DOI: 10.1002/9780470027318.a9038.
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Maji SK, Orgozalek Loo RR, Inayatullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, and Teplow DB. Amino acid position-specific contributions to amyloid β-protein oligomerization.
J. Biol. Chem.
2009;
284:
23580-23591.
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Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G , Teplow DB, Shea J-E, Ruotolo BT, Robinson CV, and Bowers MT. Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease.
Nat. Chem.
2009;
1(4):
326-331.
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Wu* C, Murray* MM, Bernstein* SL, Condron MM, Bitan G, Bowers MT, and Shea J-E. The Structure of Aβ42 C-Terminal Fragments Probed by a Combined Experimental and Theoretical Study.
J. Mol. Biol.
2009;
387(2):
492-501.
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Rahimi F, Maiti P, and Bitan G. Photo-Induced Cross-Linking of Unmodified Proteins (PICUP) Applied to Amyloidogenic Peptides.
J. Vis. Exp.
2009;
.
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Fradinger EA*,
Monien BH*,
Urbanc B,
Lomakin A,
Tan M,
Li H,
Spring SM,
Condron MM,
Cruz L,
Xie, C-W,
Benedek GB,
and Bitan G
C-terminal peptides co-assemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity.
Proc. Natl. Acad. Sci. USA.
2008;
105(37):
14175–14180.
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Condron MM,
Monien BH,
and Bitan G Synthesis and Purification of Highly Hydrophobic Peptides Derived from the C-Terminus of Amyloid β-Protein.
Open Biotechnol. J..
2008;
2(1):
87-93.
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Rahimi F,
Shanmugam A,
and Bitan G Structure-Function Relationships of Pre-Fibrillar Protein Assemblies in Alzheimer's Disease and Related Disorders.
Curr. Alz. Res..
2008;
5(3):
319-341.
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Yun S, Urbanc B, Cruz L, Bitan G, Teplow DB, and Stanely HS Role of Electrostatic Interactions in Amyloid β-Protein (Aβ) Oligomer Formation: A Discrete Molecular Dynamics Study.
Biophys. J..
2007;
94:
4064-4077.
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Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, and Lemere CA Dendrimeric Aβ1-15 is an effective immunogen in wildtype and APP-tg mice.
Neurobiol. Aging.
2007;
28(6):
813-823.
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Bitan G Structural study of metastable amyloidogenic protein oligomers by Photo-Induced Cross-linking of Unmodified Proteins.
Methods Enzymol.
2006;
413:
217-236.
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Monien BH, Apostolova LG, and Bitan G Early diagnostics and therapeutics for Alzheimer's disease - how early can we get there?.
Expert Rev. Neurother.
2006;
6(9):
1293-1306.
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Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea J-E, Urbanc B, Cruz L, Borreguero J, and Stanley HE Elucidating Amyloid β-Protein Folding and Assembly: A Multidisciplinary Approach.
Acc. Chem. Res.
2006;
39(9):
635-345.
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Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, and Shea J-E Amyloid β-protein monomer structure: A computational and experimental study.
Prot. Sci.
2006;
15:
420-428.
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Fradinger EA and Bitan G En route to early diagnosis of Alzheimer's disease--are we there yet?.
Trends Biotech.
2005;
23(11):
531-533.
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Bitan G, Fradinger EA, Spring SM, and Teplow DB Neurotoxic protein oligomers-what you see is not always what you get.
Amyloid.
2005;
12:
88-95.
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Bernstein SL, Wyttenbach T, Baumketner A, Shea J-E, Bitan G, Teplow DB, and Bowers MT Amyloid β-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.
J. Am. Chem. Soc.
2005;
127(7):
2075-2084.
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Lazo ND, Maji SK, Fradinger EA, Bitan G, and Teplow DB The Amyloid β-protein.
.
2005;
In: Sipe J, Ed. Amyloid Proteins: the β-sheet Conformation and Disease:
385-492.
Vollers SS, Teplow DB, and Bitan G Determination of peptide oligomerization state using rapid photochemical cross-linking.
Methods Mol. Biol.
2005;
299:
11-18.
Bitan G and Teplow DB Preparation of aggregate-free, low molecular weight amyloid-β for assembly and toxicity assays.
Methods Mol. Biol.
2005;
299:
3-9.
Urbanc B, Cruz L, Yun S, Buldyrev SV, Bitan G, Teplow DB, and Stanley HE In silico study of amyloid β-protein folding and oligomerization.
Proc. Natl. Acad. Sci. USA.
2004;
101(50):
17345-17350.
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Bitan G and Teplow DB Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies.
Acc. Chem. Res.
2004;
37(6):
357-364.
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Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, and Teplow DB A molecular switch in amyloid assembly: Met35 and amyloid β-protein oligomerization.
J. Am. Chem. Soc.
2003;
125(50):
15359-15365.
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Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, and Teplow DB Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways..
Proc. Natl. Acad. Sci. USA.
2003;
100(1):
330-335.
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Bitan G, Vollers SS, and Teplow DB Elucidation of primary structure elements controlling early amyloid β-protein oligomerization.
J. Biol. Chem.
2003;
278(37):
34882-34889.
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Kirkitadze MD, Bitan G, and Teplow DB Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.
J. Neurosci. Res.
2002;
69(5):
567-577.
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Bitan G, Lomakin A, and Teplow DB Amyloid β-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins.
J. Biol. Chem.
2001;
276(37):
35176-35184.
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Bitan G, Scheibler L, Teng H, Rosenblatt M, and Chorev M Design and evaluation of benzophenone-containing conformationally constrained ligands as tools for photoaffinity scanning of the integrin αVβ3-ligand bimolecular interaction.
J. Pept. Res.
2000;
55(3):
181-194.
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Bitan G, Scheibler L, Mierke DF, Rosenblatt M, and Chorev M Ligand--Integrin αVβ3 Interaction Determined by Photoaffinity Crosslinking: A Challenge to the Prevailing Model.
Biochemistry.
2000;
39:
11014-11023.
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Bitan G, Scheibler L, Greenberg Z, Teng H, Rosenblatt M, and Chorev M Mapping the Integrin αVβ3--Ligand Interface by Photoaffinity Cross-linking.
Biochemistry.
1999;
38:
3414-3420.
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Bitan G, Muller D, Kasher R, Gluhov EV, and Gilon C Building Units for N-Backbone Cyclic Peptides. Part 4. Synthesis of Protected Nα-ω-functionalized alkylamino acids by reductive alkylation of natural amino acids.
J. Chem. Soc. Perkin Trans. 1.
1997;
1501-1510.
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Muller D, Zeltser I, Bitan G, and Gilon C Building Units for N-Backbone Cyclic Peptides. Part 3. Synthesis of Protected Nα-ω-carboxyalkylene and Nα-ω-aminoalkylene Amino Acids.
J. Org. Chem.
1997;
62:
411-416.
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Bitan G, Sukhotinsky I, Mashriki Y, Hanani M, Selinger Z, and Gilon C Synthesis and biological activity of novel backbone-bicyclic substance-P analogs containing lactam and disulfide bridges.
J. Pept. Res.
1997;
49(5):
421-426.
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Bitan G, Zeltser I, Byk G, Halle D, Mashriki Y, Gluhov EV, Sukhotinsky I, Hanani M, Selinger Z, and Gilon C Backbone cyclization of the C-terminal part of substance P. Part 1: The important role of the sulphur in position 11.
J. Pept. Sci.
1996;
2(4):
261-269.
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Byk G, Halle D, Zeltser I, Bitan G, Selinger Z, and Gilon C Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P.
J. Med. Chem.
1996;
39(16):
3174-3178.
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Bitan G and Gilon C Building Units for N-Backbone Cyclic Peptides. Part 2. Synthesis of Protected Nα-ω-thioalkylene Amino Acids and Their Incorporation into Dipeptide Units.
Tetrahedron.
1995;
51:
10513-10522.
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Bitan G, Behrens S, Matha B, Mashriki Y, Hanani H, Kessler H, and Gilon C New Backbone-Cyclic Substance P Analogs.
Lett. Pept. Sci.
1995;
2:
121-124.
