Simon, Daniels, Romero-Calderòn, Grygoruk, Chang, Najibi, Shamouelian, Salazar, Solomon, Ackerson, Maidment, Diantonio, Krantz Drosophila Vesicular Monoamine Transporter Mutants can adapt to
Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin..
Genetics.
2008;
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Romero-Calderón Rafael, Uhlenbrock Guido, Borycz Jolanta, Simon Anne F, Grygoruk Anna, Yee Susan K, Shyer Amy, Ackerson Larry C, Maidment Nigel T, Meinertzhagen Ian A, Hovemann Bernhard T, Krantz David E A glial variant of the vesicular monoamine transporter is required to
store histamine in the Drosophila visual system..
PLoS genetics.
2008;
4(11):
e1000245.
Fei Hao, Grygoruk Anna, Brooks Elizabeth S, Chen Audrey, Krantz David E Trafficking of vesicular neurotransmitter transporters..
Traffic (Copenhagen, Denmark).
2008;
9(9):
1425-36.
Fei Hao, Karnezis Tara, Reimer Richard J, Krantz David E Membrane topology of the Drosophila vesicular glutamate transporter..
Journal of neurochemistry.
2007;
101(6):
1662-71.
Romero-Calderón Rafael, Shome Ratula M, Simon Anne F, Daniels Richard W, DiAntonio Aaron, Krantz David E A screen for neurotransmitter transporters expressed in the visual
system of Drosophila melanogaster identifies three novel genes..
Developmental neurobiology.
2007;
67(5):
550-69.
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I am interested in the molecular mechanisms that regulate synaptic transmission, and the relationship between changes in neurotransmitter release and neuropsychiatric illnesses such as depression and Parkinson's disease. My laboratory focuses on the function of neurotransmitter transporters, the proteins responsible for transporting neurotransmitters such as dopamine and serotonin across biological membranes. Using a variety of molecular and genetic techniques, we study how neurotransmitter transport is regulated in cultured cells and in the model organism Drosophila, and how changes in transporter function may influence behavior.
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