UCLA Neuroscience Program Ph.D. Admissions Neuroscience Faculty UCLA and Beyond  



Albert Lai
Pharmacogenomics of Glioblastoma Response to Therapy

Work Email Address:  albertlai@ mednet.ucla.edu
Laboratory: http://lailab.neurology.ucla.edu/index.html

Mailing Address:
BOX 957334, Neuroscience Research
Office Address:
635 Charles E. Young Drive
Phone Numbers:
310-825-0644 FAX
Phone Numbers:
310-825-5321 Office

Selected Publications:

Pope, W. B. Kim, H. J. Huo, J. Alger, J. Brown, M. S. Gjertson, D. Sai, V. Young, J. R. Tekchandani, L. Cloughesy, T. Mischel, P. S. Lai, A. Nghiemphu, P. Rahmanuddin, S. Goldin, J. Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology. 2009; 252(1): 182-9.
Remington, M. Chtchetinin, J. Ancheta, K. Nghiemphu, P. L. Cloughesy, T. Lai, A. The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity. Neuro Oncol. 2009; 11(1): 22-32.
Pope, W. B. Chen, J. H. Dong, J. Carlson, M. R. Perlina, A. Cloughesy, T. F. Liau, L. M. Mischel, P. S. Nghiemphu, P. Lai, A. Nelson, S. F. Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis. Radiology. 2008; 249(1): 268-77.
Nghiemphu, P. L. Liu, W. Lee, Y. Than, T. Graham, C. Lai, A. Green, R. M. Pope, W. B. Liau, L. M. Mischel, P. S. Nelson, S. F. Elashoff, R. Cloughesy, T. F. Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience. Neurology. 2009; 72(14): 1217-22.
Lee, Y. Scheck, A. C. Cloughesy, T. F. Lai, A. Dong, J. Farooqi, H. K. Liau, L. M. Horvath, S. Mischel, P. S. Nelson, S. F. Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age. BMC Med Genomics. 2008; 1(1): 52.
Nghiemphu, P. L. Green, R. M. Pope, W. B. Lai, A. Cloughesy, T. F. Safety of anticoagulation use and bevacizumab in patients with glioma. Neuro Oncol. 2008; volume(number): pages.
Ananthnarayan, S. Bahng, J. Roring, J. Nghiemphu, P. Lai, A. Cloughesy, T. Pope, W. B. Time course of imaging changes of GBM during extended bevacizumab treatment. J Neurooncol. 2008; volume(number): pages.
Ananthnarayan, S. Bahng, J. Roring, J. Nghiemphu, P. Lai, A. Cloughesy, T. Pope, W. B. Time course of imaging changes of GBM during extended bevacizumab treatment. J Neurooncol. 2008; volume(number): pages.
Lai, A. Filka, E. McGibbon, B. Nghiemphu, P. L. Graham, C. Yong, W. H. Mischel, P. Liau, L. M. Bergsneider, M. Pope, W. Selch, M. Cloughesy, T. Phase II Pilot Study of Bevacizumab in Combination With Temozolomide and Regional Radiation Therapy for Up-Front Treatment of Patients With Newly Diagnosed Glioblastoma Multiforme: Interim Analysis of Safety and Tolerability. Int J Radiat Oncol Biol Phys. 2008; volume(number): pages.
Cloughesy, T. F. Yoshimoto, K. Nghiemphu, P. Brown, K. Dang, J. Zhu, S. Hsueh, T. Chen, Y. Wang, W. Youngkin, D. Liau, L. Martin, N. Becker, D. Bergsneider, M. Lai, A. Green, R. Oglesby, T. Koleto, M. Trent, J. Horvath, S. Mischel, P. S. Mellinghoff, I. K. Sawyers, C. L. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 2008; 5(1): e8.
Chen, W. Delaloye, S. Silverman, D. H. Geist, C. Czernin, J. Sayre, J. Satyamurthy, N. Pope, W. Lai, A. Phelps, M. E. Cloughesy, T. Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. J Clin Oncol. 2007; 25(30): 4714-21.
Carlson, M. R. Pope, W. B. Horvath, S. Braunstein, J. G. Nghiemphu, P. Tso, C. L. Mellinghoff, I. Lai, A. Liau, L. M. Mischel, P. S. Dong, J. Nelson, S. F. Cloughesy, T. F. Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2. Clin Cancer Res. 2007; 13(9): 2592-8.
Pope, W. B. Lai, A. Nghiemphu, P. Mischel, P. Cloughesy, T. F. MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology. 2006; 66(8): 1258-60.
Lai, A. Le, D. N. Paznekas, W. A. Gifford, W. D. Jabs, E. W. Charles, A. C. Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells. J Cell Sci. 2006; 119(Pt 3): 532-41.
Lai, A. Gibson, A. Hopkins, C. R. Trowbridge, I. S. Signal-dependent trafficking of beta-amyloid precursor protein-transferrin receptor chimeras in madin-darby canine kidney cells. J Biol Chem. 1998; 273(6): 3732-9.
Lai, A. Sisodia, S. S. Trowbridge, I. S. Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain. J Biol Chem. 1995; 270(8): 3565-73.
Collawn, J. F. Lai, A. Domingo, D. Fitch, M. Hatton, S. Trowbridge, I. S. YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis. J Biol Chem. 1993; 268(29): 21686-92.
Research Interest:

Pharmacogenomics of glioblastoma response to therapy focusing on MGMT promoter methylation and MGMT polymorphisms with a secondary interest in mechanisms of glioma migration.