UCLA Neuroscience Program Ph.D. Admissions Neuroscience Faculty UCLA and Beyond  



James Jentsch
Neuropsychopharmacology; Animal Models of Neuropsychiatric Disorders

Email Address:  jentsch@psych.ucla.edu

Work Address:
Franz Hall


Phone Numbers:
310-825-8258 Office


Selected Publications:

Groman Stephanie M, Morales Angelica M, Lee Buyean, London Edythe D, Jentsch James David Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology. 2013; 229(3): 527-38.
James Alex S, Chen Jane Y, Cepeda Carlos, Mittal Nitish, Jentsch James David, Levine Michael S, Evans Christopher J, Walwyn Wendy Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons. Behavioural brain research. 2013; 256C(3): 279-283.
Groman Stephanie M, James Alex S, Seu Emanuele, Crawford Maverick A, Harpster Sandra N, Jentsch James David Monoamine levels within the orbitofrontal cortex and putamen interact to predict reversal learning performance. Biological psychiatry. 2013; 73(8): 756-62.
Floresco Stan B, Jentsch James D Pharmacological enhancement of memory and executive functioning in laboratory animals. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011; 36(1): 227-50.
Jentsch James David, Woods Jason A, Groman Stephanie M, Seu Emanuele Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the Balloon Analog Risk Task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010; 35(8): 1797-806.
Jentsch James David, Trantham-Davidson Heather, Jairl Corey, Tinsley Matthew, Cannon Tyrone D, Lavin Antonieta Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009; 34(12): 2601-8.
Seu, Jentsch Effect of acute and repeated treatment with desipramine or methylphenidate on serial reversal learning in rats. Neuropharmacology. 2009; .
Jasinska, Service, Choi, Deyoung, Grujic, Kong, Jorgensen, Bailey, Breidenthal, Fairbanks, Woods, Jentsch, Freimer Identification of Brain Transcriptional Variation Reproduced in Peripheral Blood: an Approach for Mapping Brain Expression Traits. Human molecular genetics. 2009; .
Groman Stephanie M, James Alex S, Jentsch J David Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder. Neuroscience and biobehavioral reviews. 2009; 33(5): 690-8.
Jentsch J David, Aarde Shawn M, Seu Emanuele Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats. Psychopharmacology. 2009; 202(1-3): 497-504.
Seu Emanuele, Lang Andrew, Rivera Ronald J, Jentsch J David Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys. Psychopharmacology. 2009; 202(1-3): 505-19.
Bilder J David, Sabb J David, Cannon J David, London J David, Jentsch J David, Parker J David, Poldrack J David, Evans J David, Freimer J David Phenomics: The systematic study of phenotypes on a genome-wide scale. Neuroscience. 2009; 33(5): .
Jentsch J David, Sanchez Diana, Elsworth John D, Roth Robert H Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain research. 2008; 1246(1-3): 41-6.
Kalechstein Ari D, Jentsch J David, Kantak Kathleen M Stimulant-associated cognitive abnormalities: mechanisms and impact on reward-related behavior and addiction. Drug and alcohol dependence. 2008; 97(3): 276-80.
Elsworth John D, Jentsch J David, Morrow Bret A, Redmond D Eugene, Roth Robert H Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008; 33(3): 491-6.
James Alex S, Groman Stephanie M, Seu Emanuele, Jorgensen Matthew, Fairbanks Lynn A, Jentsch J David Dimensions of impulsivity are associated with poor spatial working memory performance in monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007; 27(52): 14358-64.
Olausson Peter, Jentsch J David, Krueger Dilja D, Tronson Natalie C, Nairn Angus C, Taylor Jane R Orbitofrontal cortex and cognitive-motivational impairments in psychostimulant addiction: evidence from experiments in the non-human primate. Annals of the New York Academy of Sciences. 2007; 1121(52): 610-38.
Li Weidong, Zhou Yu, Jentsch J David, Brown Robert A M, Tian Xiaoli, Ehninger Dan, Hennah William, Peltonen Leena, Lönnqvist Jouko, Huttunen Matti O, Kaprio Jaakko, Trachtenberg Joshua T, Silva Alcino J, Cannon Tyrone D Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(46): 18280-5.
Lee Buyean, Groman Stephanie, London Edythe D, Jentsch James David Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2007; 32(10): 2125-34.
Olausson Peter, Jentsch J David, Tronson Natalie, Neve Rachel L, Nestler Eric J, Taylor Jane R DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006; 26(36): 9196-204.
Moore Holly, Jentsch J David, Ghajarnia Mehdi, Geyer Mark A, Grace Anthony A A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biological psychiatry. 2006; 60(3): 253-64.
Aarde Shawn M, Jentsch J David Haploinsufficiency of the arginine-vasopressin gene is associated with poor spatial working memory performance in rats. Hormones and behavior. 2006; 49(4): 501-8.
Li Weidong, Cui Yijun, Kushner Steven A, Brown Robert A M, Jentsch J David, Frankland Paul W, Cannon Tyrone D, Silva Alcino J The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Current biology : CB. 2005; 15(21): 1961-7.
Lue Yanhe, Jentsch J David, Wang Christina, Rao P Nagesh, Hikim Amiya P Sinha, Salameh Wael, Swerdloff Ronald S XXY mice exhibit gonadal and behavioral phenotypes similar to Klinefelter syndrome. Endocrinology. 2005; 146(9): 4148-54.
Marrs William, Kuperman Julie, Avedian Tahlin, Roth Robert H, Jentsch J David Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2005; 30(8): 1500-10.
Jentsch J David Impaired visuospatial divided attention in the spontaneously hypertensive rat. Behavioural brain research. 2005; 157(2): 323-30.
Arguello P Alexander, Jentsch J David Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat. Psychopharmacology. 2004; 177(1-2): 141-50.
Jentsch J David, Anzivino Luigi A A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats. Psychopharmacology. 2004; 175(1): 76-83.
Research Interest:

Genetic and neurochemical determinants of cognitive and executive functions; mechanisms of action of psychotherapeutic drugs; novel strategies for modulating cognitive deficits in schizophrenia, addiction and AD/HD; animal models for psychiatric disorders