Gdalyahu Amos, Tring Elaine, Polack Pierre-Olivier, Gruver Robin, Golshani Peyman, Fanselow Michael S, Silva Alcino J, Trachtenberg Joshua T Associative fear learning enhances sparse network coding in primary
sensory cortex..
Neuron.
2012;
75(1):
121-32.
Cho Jeiwon, Bhatt Rushi, Elgersma Ype, Silva Alcino J α-Calcium calmodulin kinase II modulates the temporal structure of
hippocampal bursting patterns..
PloS one.
2012;
7(2):
e31649.
Lee Yong-Seok, Silva Alcino J Modeling hyperactivity: of mice and men..
Nature medicine.
2011;
17(5):
541-2.
Kye Min Jeong, Neveu Pierre, Lee Yong-Seok, Zhou Miou, Steen Judith A, Sahin Mustafa, Kosik Kenneth S, Silva Alcino J NMDA mediated contextual conditioning changes miRNA expression..
PloS one.
2011;
6(9):
e24682.
Shilyansky Carrie, Karlsgodt Katherine H, Cummings Damian M, Sidiropoulou Kyriaki, Hardt Molly, James Alex S, Ehninger Dan, Bearden Carrie E, Poirazi Panayiota, Jentsch J David, Cannon Tyrone D, Levine Michael S, Silva Alcino J Neurofibromin regulates corticostriatal inhibitory networks during
working memory performance..
Proceedings of the National Academy of Sciences of the United States of America.
2010;
107(29):
13141-6.
Feng Jian, Zhou Yu, Campbell Susan L, Le Thuc, Li En, Sweatt J David, Silva Alcino J, Fan Guoping Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic
function in adult forebrain neurons..
Nature neuroscience.
2010;
13(4):
423-30.
Matynia Anna, Ng Carina Hoi, Dansithong Warunee, Chiang Andy, Silva Alcino J, Reddy Sita Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype
of muscular and motivational deficits in mouse models of myotonic
dystrophy..
PloS one.
2010;
5(3):
e9857.
Zhou Yu, Won Jaejoon, Karlsson Mikael Guzman, Zhou Miou, Rogerson Thomas, Balaji Jayaprakash, Neve Rachael, Poirazi Panayiota, Silva Alcino J CREB regulates excitability and the allocation of memory to subsets of
neurons in the amygdala..
Nature neuroscience.
2009;
12(11):
1438-43.
Silva Alcino J, Zhou Yu, Rogerson Thomas, Shobe Justin, Balaji J Molecular and cellular approaches to memory allocation in neural
circuits..
Science (New York, N.Y.).
2009;
326(5951):
391-5.
Hutnick Leah K, Golshani Peyman, Namihira Masakasu, Xue Zhigang, Matynia Anna, Yang X William, Silva Alcino J, Schweizer Felix E, Fan Guoping DNA hypomethylation restricted to the murine forebrain induces
cortical degeneration and impairs postnatal neuronal maturation..
Human molecular genetics.
2009;
18(15):
2875-88.
Ehninger Dan, Silva Alcino J Genetics and neuropsychiatric disorders: treatment during adulthood..
Nature medicine.
2009;
15(8):
849-50.
Ehninger Dan, Li Weidong, Fox Kevin, Stryker Michael P, Silva Alcino J Reversing neurodevelopmental disorders in adults..
Neuron.
2008;
60(6):
950-60.
Cui Yijun, Costa Rui M, Murphy Geoffrey G, Elgersma Ype, Zhu Yuan, Gutmann David H, Parada Luis F, Mody Istvan, Silva Alcino J Neurofibromin regulation of ERK signaling modulates GABA release and
learning..
Cell.
2008;
135(3):
549-60.
Ehninger Dan, Han Sangyeul, Shilyansky Carrie, Zhou Yu, Li Weidong, Kwiatkowski David J, Ramesh Vijaya, Silva Alcino J Reversal of learning deficits in a Tsc2+/- mouse model of tuberous
sclerosis..
Nature medicine.
2008;
14(8):
843-8.
Matynia Anna, Anagnostaras Stephan G, Wiltgen Brian J, Lacuesta Maress, Fanselow Michael S, Silva Alcino J A high through-put reverse genetic screen identifies two genes
involved in remote memory in mice..
PloS one.
2008;
3(5):
e2121.
Li Weidong, Zhou Yu, Jentsch J David, Brown Robert A M, Tian Xiaoli, Ehninger Dan, Hennah William, Peltonen Leena, Lönnqvist Jouko, Huttunen Matti O, Kaprio Jaakko, Trachtenberg Joshua T, Silva Alcino J, Cannon Tyrone D Specific developmental disruption of disrupted-in-schizophrenia-1
function results in schizophrenia-related phenotypes in mice..
Proceedings of the National Academy of Sciences of the United States of America.
2007;
104(46):
18280-5.
Silva Alcino J The science of research: the principles underlying the discovery of
cognitive and other biological mechanisms..
Journal of physiology, Paris.
2007;
101(4-6):
203-13.
Chen Adele P, Ohno Masuo, Giese K Peter, Kühn Ralf, Chen Rachel L, Silva Alcino J Forebrain-specific knockout of B-raf kinase leads to deficits in
hippocampal long-term potentiation, learning, and memory..
Journal of neuroscience research.
2006;
83(1):
28-38.
Li Weidong, Cui Yijun, Kushner Steven A, Brown Robert A M, Jentsch J David, Frankland Paul W, Cannon Tyrone D, Silva Alcino J The HMG-CoA reductase inhibitor lovastatin reverses the learning and
attention deficits in a mouse model of neurofibromatosis type 1..
Current biology : CB.
2005;
15(21):
1961-7.
Kushner Steven A, Elgersma Ype, Murphy Geoffrey G, Jaarsma Dick, van Woerden Geeske M, Hojjati Mohammad Reza, Cui Yijun, LeBoutillier Janelle C, Marrone Diano F, Choi Esther S, De Zeeuw Chris I, Petit Ted L, Pozzo-Miller Lucas, Silva Alcino J Modulation of presynaptic plasticity and learning by the
H-ras/extracellular signal-regulated kinase/synapsin I signaling
pathway..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005;
25(42):
9721-34.
Ehninger Dan, Matynia Anna, Silva Alcino J Trafficking in emotions..
Nature neuroscience.
2005;
8(5):
548-50.
Murphy Geoffrey G, Fedorov Nikolai B, Giese K Peter, Ohno Masuo, Friedman Eugenia, Chen Rachel, Silva Alcino J Increased neuronal excitability, synaptic plasticity, and learning in
aged Kvbeta1.1 knockout mice..
Current biology : CB.
2004;
14(21):
1907-15.
Israely Inbal, Costa Rui M, Xie Cui Wei, Silva Alcino J, Kosik Kenneth S, Liu Xin Deletion of the neuron-specific protein delta-catenin leads to severe
cognitive and synaptic dysfunction..
Current biology : CB.
2004;
14(18):
1657-63.
Wiltgen Brian J, Brown Robert A M, Talton Lynn E, Silva Alcino J New circuits for old memories: the role of the neocortex in
consolidation..
Neuron.
2004;
44(1):
101-8.
Frankland Paul W, Bontempi Bruno, Talton Lynn E, Kaczmarek Leszek, Silva Alcino J The involvement of the anterior cingulate cortex in remote contextual
fear memory..
Science (New York, N.Y.).
2004;
304(5672):
881-3.
Frankland Paul W, Josselyn Sheena A, Anagnostaras Stephan G, Kogan Jeffrey H, Takahashi Eiki, Silva Alcino J Consolidation of CS and US representations in associative fear
conditioning..
Hippocampus.
2004;
14(5):
557-69.
Brown Robert, Silva Alcino J Molecular and cellular cognition; the unraveling of memory retrieval..
Cell.
2004;
117(1):
3-4.
Costa Rui M, Honjo Tasuku, Silva Alcino J Learning and memory deficits in Notch mutant mice..
Current biology : CB.
2003;
13(15):
1348-54.
Silva Alcino J Molecular and cellular cognitive studies of the role of synaptic
plasticity in memory..
Journal of neurobiology.
2003;
54(1):
224-37.
Anagnostaras Stephan G, Murphy Geoffrey G, Hamilton Susan E, Mitchell Scott L, Rahnama Nancy P, Nathanson Neil M, Silva Alcino J Selective cognitive dysfunction in acetylcholine M1 muscarinic
receptor mutant mice..
Nature neuroscience.
2003;
6(1):
51-8.
Elgersma Ype, Fedorov Nikolai B, Ikonen Sami, Choi Esther S, Elgersma Minetta, Carvalho Ofelia M, Giese Karl Peter, Silva Alcino J Inhibitory autophosphorylation of CaMKII controls PSD association,
plasticity, and learning..
Neuron.
2002;
36(3):
493-505.
Costa Rui M, Silva Alcino J Molecular and cellular mechanisms underlying the cognitive deficits
associated with neurofibromatosis 1..
Journal of child neurology.
2002;
17(8):
622-6; discussion 627-9, 646-51.
Silva Alcino J, Josselyn Sheena A The molecules of forgetfulness..
Nature.
2002;
418(6901):
929-30.
Ohno Masuo, Frankland Paul W, Silva Alcino J A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII
signaling in synaptic plasticity..
Current biology : CB.
2002;
12(8):
654-6.
Kida Satoshi, Josselyn Sheena A, Peña de Ortiz Sandra, Kogan Jeffrey H, Chevere Itzamarie, Masushige Shoichi, Silva Alcino J CREB required for the stability of new and reactivated fear memories..
Nature neuroscience.
2002;
5(4):
348-55.
Givogri Maria I, Costa Rui M, Schonmann Vilma, Silva Alcino J, Campagnoni Anthony T, Bongarzone Ernesto R Central nervous system myelination in mice with deficient expression
of Notch1 receptor..
Journal of neuroscience research.
2002;
67(3):
309-20.
Matynia Anna, Kushner Steven A, Silva Alcino J Genetic approaches to molecular and cellular cognition: a focus on LTP
and learning and memory..
Annual review of genetics.
2002;
36(6871):
687-720.
Costa Rui M, Federov Nikolai B, Kogan Jeff H, Murphy Geoffrey G, Stern Joel, Ohno Masuo, Kucherlapati Raju, Jacks Tyler, Silva Alcino J Mechanism for the learning deficits in a mouse model of
neurofibromatosis type 1..
Nature.
2002;
415(6871):
526-30.
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Our laboratory is studying the biology of learning and memory. We are interested in the molecular, cellular and circuit processes that underlie the storage, recall and allocation of information. To accomplish this we are using a variety of techniques including transgenic manipulations, pharmacology, in vitro and in vivo electrophysiology, optogenetics, optophysiology, neuroanatomical lesions and behavioral analysis. The focus of our studies has been on hippocampal dependent learning and memory. Our results implicate a variety of hippocampal mechanisms in learning and memory, including long term potentiation, short term plasticity, and the slow afterhyperpolarization. Our laboratory is also interested in applying these findings to the development of treatments for learning and memory disorders, such as those observed with aging, autism, schizophrenia, and in neurofibromatosis type I.
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