Cepeda, C., Hurst, R.S., Altemus, K.L., Flores-Hern ndez, J., Calvert, C.R, Jokel, E.S., Grandy, D.K., Low, M.J., Rubinstein, M., Ariano, M.A. and Levine, M.S. Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice..
J. Neurophysiol.
2001;
85:
659-670.
Cepeda, C and Levine, M.S. Dopamine and NMDA receptor interactions in the neostriatum..
Dev. Neurosci
1998;
20:
1-18.
Cepeda Carlos, Levine Michael S 2B or Not 2B: A Tail of Two NMDA Receptor Subunits..
Neuron.
2012;
74(3):
426-8.
Hickey Miriam A, Zhu Chunni, Medvedeva Vera, Lerner Renata P, Patassini Stefano, Franich Nicholas R, Maiti Panchanan, Frautschy Sally A, Zeitlin Scott, Levine Michael S, Chesselet Marie-Françoise Improvement of neuropathology and transcriptional deficits in CAG 140
knock-in mice supports a beneficial effect of dietary curcumin in
Huntington's disease..
Molecular neurodegeneration.
2012;
7(3):
12.
Ma Yao-Ying, Cepeda Carlos, Chatta Payush, Franklin Lana, Evans Christopher J, Levine Michael S Regional and cell-type-specific effects of DAMGO on striatal D1 and D2
dopamine receptor-expressing medium-sized spiny neurons..
ASN neuro.
2012;
4(2):
.
Hickey Miriam A, Zhu Chunni, Medvedeva Vera, Franich Nicholas R, Levine Michael S, Chesselet Marie-Françoise Evidence for behavioral benefits of early dietary supplementation with
CoEnzymeQ10 in a slowly progressing mouse model of Huntington's
disease..
Molecular and cellular neurosciences.
2012;
49(2):
149-57.
Cummings Damian M, Alaghband Yasaman, Hickey Miriam A, Joshi Prasad R, Hong S Candice, Zhu Chunni, Ando Timothy K, André Véronique M, Cepeda Carlos, Watson Joseph B, Levine Michael S A critical window of CAG repeat-length correlates with phenotype
severity in the R6/2 mouse model of Huntington's disease..
Journal of neurophysiology.
2012;
107(2):
677-91.
Cepeda Carlos, André Véronique M, Hauptman Jason S, Yamazaki Irene, Huynh My N, Chang Julia W, Chen Jane Y, Fisher Robin S, Vinters Harry V, Levine Michael S, Mathern Gary W Enhanced GABAergic network and receptor function in pediatric cortical
dysplasia Type IIB compared with Tuberous Sclerosis Complex..
Neurobiology of disease.
2012;
45(1):
310-21.
Lam Hoa A, Wu Nanping, Cely Ingrid, Kelly Rachel L, Hean Sindalana, Richter Franziska, Magen Iddo, Cepeda Carlos, Ackerson Larry C, Walwyn Wendy, Masliah Eliezer, Chesselet Marie-Françoise, Levine Michael S, Maidment Nigel T Elevated tonic extracellular dopamine concentration and altered
dopamine modulation of synaptic activity precede dopamine loss in the
striatum of mice overexpressing human α-synuclein..
Journal of neuroscience research.
2011;
89(7):
1091-102.
Kim Soong Ho, Thomas Carlos A, André Véronique M, Cummings Damian M, Cepeda Carlos, Levine Michael S, Ehrlich Michelle E Forebrain striatal-specific expression of mutant huntingtin protein in
vivo induces cell-autonomous age-dependent alterations in sensitivity
to excitotoxicity and mitochondrial function..
ASN neuro.
2011;
3(3):
e00060.
André Véronique M, Fisher Yvette E, Levine Michael S Altered Balance of Activity in the Striatal Direct and Indirect
Pathways in Mouse Models of Huntington's Disease..
Frontiers in systems neuroscience.
2011;
5(4):
46.
Jocoy Emily L, André Véronique M, Cummings Damian M, Rao Shilpa P, Wu Nanping, Ramsey Amy J, Caron Marc G, Cepeda Carlos, Levine Michael S Dissecting the contribution of individual receptor subunits to the
enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor
activation in striatum..
Frontiers in systems neuroscience.
2011;
5(4):
28.
Cummings Damian M, Cepeda Carlos, Levine Michael S Alterations in striatal synaptic transmission are consistent across
genetic mouse models of Huntington's disease..
ASN neuro.
2010;
2(3):
e00036.
Cepeda Carlos, André Véronique M, Yamazaki Irene, Hauptman Jason S, Chen Jane Y, Vinters Harry V, Mathern Gary W, Levine Michael S Comparative study of cellular and synaptic abnormalities in brain
tissue samples from pediatric tuberous sclerosis complex and cortical
dysplasia type II..
Epilepsia.
2010;
51 Suppl 3(29):
160-5.
André Véronique M, Cepeda Carlos, Vinters Harry V, Huynh My, Mathern Gary W, Levine Michael S Interneurons, GABAA currents, and subunit composition of the GABAA
receptor in type I and type II cortical dysplasia..
Epilepsia.
2010;
51 Suppl 3(29):
166-70.
Shilyansky Carrie, Karlsgodt Katherine H, Cummings Damian M, Sidiropoulou Kyriaki, Hardt Molly, James Alex S, Ehninger Dan, Bearden Carrie E, Poirazi Panayiota, Jentsch J David, Cannon Tyrone D, Levine Michael S, Silva Alcino J Neurofibromin regulates corticostriatal inhibitory networks during
working memory performance..
Proceedings of the National Academy of Sciences of the United States of America.
2010;
107(29):
13141-6.
Wu Nanping, Joshi Prasad R, Cepeda Carlos, Masliah Eliezer, Levine Michael S Alpha-synuclein overexpression in mice alters synaptic communication
in the corticostriatal pathway..
Journal of neuroscience research.
2010;
88(8):
1764-76.
André Véronique M, Cepeda Carlos, Levine Michael S Dopamine and glutamate in Huntington's disease: A balancing act..
CNS neuroscience & therapeutics.
2010;
16(3):
163-78.
Cepeda Carlos, Cummings Damian M, André Véronique M, Holley Sandra M, Levine Michael S Genetic mouse models of Huntington's disease: focus on
electrophysiological mechanisms..
ASN neuro.
2010;
2(2):
e00033.
André Véronique M, Cepeda Carlos, Cummings Damian M, Jocoy Emily L, Fisher Yvette E, William Yang X, Levine Michael S Dopamine modulation of excitatory currents in the striatum is dictated
by the expression of D1 or D2 receptors and modified by
endocannabinoids..
The European journal of neuroscience.
2010;
31(1):
14-28.
Levine Michael S, Cepeda Carlos, André Véronique M Location, location, location: contrasting roles of synaptic and
extrasynaptic NMDA receptors in Huntington's disease..
Neuron.
2010;
65(2):
145-7.
Cepeda Carlos, Cummings Damian M, Hickey Miriam A, Kleiman-Weiner Max, Chen Jane Y, Watson Joseph B, Levine Michael S Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse
Model of Huntington's Disease: Exercise, Adenosine Receptors and
Ampakines..
PLoS currents.
2010;
2(4):
.
Lerner Jason T, Salamon Noriko, Hauptman Jason S, Velasco Tonicarlo R, Hemb Marta, Wu Joyce Y, Sankar Raman, Donald Shields W, Engel Jerome, Fried Itzhak, Cepeda Carlos, Andre Veronique M, Levine Michael S, Miyata Hajime, Yong William H, Vinters Harry V, Mathern Gary W Assessment and surgical outcomes for mild type I and severe type II
cortical dysplasia: a critical review and the UCLA experience..
Epilepsia.
2009;
50(6):
1310-35.
Joshi Prasad R, Wu Nan-Ping, André Véronique M, Cummings Damian M, Cepeda Carlos, Joyce John A, Carroll Jeffrey B, Leavitt Blair R, Hayden Michael R, Levine Michael S, Bamford Nigel S Age-dependent alterations of corticostriatal activity in the YAC128
mouse model of Huntington disease..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009;
29(8):
2414-27.
Graham Rona K, Pouladi Mahmoud A, Joshi Prasad, Lu Ge, Deng Yu, Wu Nan-Ping, Figueroa Bryan E, Metzler Martina, André Véronique M, Slow Elizabeth J, Raymond Lynn, Friedlander Robert, Levine Michael S, Leavitt Blair R, Hayden Michael R Differential susceptibility to excitotoxic stress in YAC128 mouse
models of Huntington disease between initiation and progression of
disease..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009;
29(7):
2193-204.
Graham Rona K, Pouladi Mahmoud A, Joshi Prasad, Lu Ge, Deng Yu, Wu Nan-Ping, Figueroa Bryan E, Metzler Martina, André Véronique M, Slow Elizabeth J, Raymond Lynn, Friedlander Robert, Levine Michael S, Leavitt Blair R, Hayden Michael R Differential susceptibility to excitotoxic stress in YAC128 mouse
models of Huntington disease between initiation and progression of
disease..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009;
29(7):
2193-204.
André Véronique M, Cepeda Carlos, Vinters Harry V, Huynh My, Mathern Gary W, Levine Michael S Pyramidal cell responses to gamma-aminobutyric acid differ in type I
and type II cortical dysplasia..
Journal of neuroscience research.
2008;
86(14):
3151-62.
Hong Joung-Woo, Hendrix David A, Levine Michael S Shadow enhancers as a source of evolutionary novelty..
Science (New York, N.Y.).
2008;
321(5894):
1314.
Cummings Damian M, Yamazaki Irene, Cepeda Carlos, Paul David L, Levine Michael S Neuronal coupling via connexin36 contributes to spontaneous synaptic
currents of striatal medium-sized spiny neurons..
Journal of neuroscience research.
2008;
86(10):
2147-58.
Gray Michelle, Shirasaki Dyna I, Cepeda Carlos, André Véronique M, Wilburn Brian, Lu Xiao-Hong, Tao Jifang, Yamazaki Irene, Li Shi-Hua, Sun Yi E, Li Xiao-Jiang, Levine Michael S, Yang X William Full-length human mutant huntingtin with a stable polyglutamine repeat
can elicit progressive and selective neuropathogenesis in BACHD mice..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008;
28(24):
6182-95.
Bamford Nigel S, Zhang Hui, Joyce John A, Scarlis Christine A, Hanan Whitney, Wu Nan-Ping, André Véronique M, Cohen Rachel, Cepeda Carlos, Levine Michael S, Harleton Erin, Sulzer David Repeated exposure to methamphetamine causes long-lasting presynaptic
corticostriatal depression that is renormalized with drug
readministration..
Neuron.
2008;
58(1):
89-103.
Cepeda Carlos, André Véronique M, Yamazaki Irene, Wu Nanping, Kleiman-Weiner Max, Levine Michael S Differential electrophysiological properties of dopamine D1 and D2
receptor-containing striatal medium-sized spiny neurons..
The European journal of neuroscience.
2008;
27(3):
671-82.
Wu Nanping, Cepeda Carlos, Zhuang Xiaoxi, Levine Michael S Altered corticostriatal neurotransmission and modulation in dopamine
transporter knock-down mice..
Journal of neurophysiology.
2007;
98(1):
423-32.
André Véronique M, Wu Nanping, Yamazaki Irene, Nguyen Snow T, Fisher Robin S, Vinters Harry V, Mathern Gary W, Levine Michael S, Cepeda Carlos Cytomegalic interneurons: a new abnormal cell type in severe pediatric
cortical dysplasia..
Journal of neuropathology and experimental neurology.
2007;
66(6):
491-504.
Gu Xiaofeng, André Véronique M, Cepeda Carlos, Li Shi-Hua, Li Xiao-Jiang, Levine Michael S, Yang X William Pathological cell-cell interactions are necessary for striatal
pathogenesis in a conditional mouse model of Huntington's disease..
Molecular neurodegeneration.
2007;
2(6):
8.
Cepeda Carlos, Wu Nanping, André Véronique M, Cummings Damian M, Levine Michael S The corticostriatal pathway in Huntington's disease..
Progress in neurobiology.
2007;
81(5-6):
253-71.
Mathern Gary W, Andres Marissa, Salamon Noriko, Chandra P Sarat, Andre Veronique M, Cepeda Carlos, Levine Michael S, Leite Joao P, Neder Luciano, Vinters Harry V A hypothesis regarding the pathogenesis and epileptogenesis of
pediatric cortical dysplasia and hemimegalencephaly based on MRI
cerebral volumes and NeuN cortical cell densities..
Epilepsia.
2007;
48 Suppl 5(2):
74-8.
Chesselet Marie-Françoise, Plotkin Joshua L, Wu Nanping, Levine Michael S Development of striatal fast-spiking GABAergic interneurons..
Progress in brain research.
2007;
160(2):
261-72.
Hernández-Echeagaray Elizabeth, Cepeda Carlos, Ariano Marjorie A, Lobo Mary Kay, Sibley David R, Levine Michael S Dopamine reduction of GABA currents in striatal medium-sized spiny
neurons is mediated principally by the D(1) receptor subtype..
Neurochemical research.
2007;
32(2):
229-40.
Cepeda Carlos, André Véronique M, Wu Nanping, Yamazaki Irene, Uzgil Besim, Vinters Harry V, Levine Michael S, Mathern Gary W Immature neurons and GABA networks may contribute to epileptogenesis
in pediatric cortical dysplasia..
Epilepsia.
2007;
48 Suppl 5(2):
79-85.
Cepeda Carlos, Levine Michael S Dysfunctional channels are making noise in CAG triplet repeat
disorders..
Experimental neurology.
2006;
202(2):
267-70.
Cepeda Carlos, André Véronique M, Levine Michael S, Salamon Noriko, Miyata Hajime, Vinters Harry V, Mathern Gary W Epileptogenesis in pediatric cortical dysplasia: the dysmature
cerebral developmental hypothesis..
Epilepsy & behavior : E&B.
2006;
9(2):
219-35.
André Véronique M, Cepeda Carlos, Venegas Angela, Gomez Yeranui, Levine Michael S Altered cortical glutamate receptor function in the R6/2 model of
Huntington's disease..
Journal of neurophysiology.
2006;
95(4):
2108-19.
Ali Noore J, Levine Michael S Changes in expression of N-methyl-D-aspartate receptor subunits occur
early in the R6/2 mouse model of Huntington's disease..
Developmental neuroscience.
2006;
28(3):
230-8.
Salamon Noriko, Andres Marissa, Chute Dennis J, Nguyen Snow T, Chang Julia W, Huynh My N, Chandra P Sarat, Andre Veronique M, Cepeda Carlos, Levine Michael S, Leite Joao P, Neder Luciano, Vinters Harry V, Mathern Gary W Contralateral hemimicrencephaly and clinical-pathological correlations
in children with hemimegalencephaly..
Brain : a journal of neurology.
2006;
129(Pt 2):
352-65.
Starling Amaal J, André Véronique M, Cepeda Carlos, de Lima Marianne, Chandler Scott H, Levine Michael S Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium
blockade occur early in development in the R6/2 mouse model of
Huntington's disease..
Journal of neuroscience research.
2005;
82(3):
377-86.
Plotkin Joshua L, Wu Nanping, Chesselet Marie-Françoise, Levine Michael S Functional and molecular development of striatal fast-spiking
GABAergic interneurons and their cortical inputs..
The European journal of neuroscience.
2005;
22(5):
1097-108.
Ariano Marjorie A, Cepeda Carlos, Calvert Christopher R, Flores-Hernández Jorge, Hernández-Echeagaray Elizabeth, Klapstein Gloria J, Chandler Scott H, Aronin Neil, DiFiglia Marian, Levine Michael S Striatal potassium channel dysfunction in Huntington's disease
transgenic mice..
Journal of neurophysiology.
2005;
93(5):
2565-74.
Gajendiran Mahadevan, Cepeda Carlos, Kha Hoa Ton, Sison Jessica D, Levine Michael S Electrophysiological alterations in subthalamic neurons after
unilateral dopamine depletion in the rat..
Journal of neuroscience research.
2005;
80(2):
203-10.
Klapstein Gloria J, Levine Michael S Age-dependent biphasic changes in ischemic sensitivity in the striatum
of Huntington's disease R6/2 transgenic mice..
Journal of neurophysiology.
2005;
93(2):
758-65.
Cepeda Carlos, André Véronique M, Vinters Harry V, Levine Michael S, Mathern Gary W Are cytomegalic neurons and balloon cells generators of epileptic
activity in pediatric cortical dysplasia?.
Epilepsia.
2005;
46 Suppl 5(2):
82-8.
Andres Marissa, Andre Veronique M, Nguyen Snow, Salamon Noriko, Cepeda Carlos, Levine Michael S, Leite Joao P, Neder Luciano, Vinters Harry V, Mathern Gary W Human cortical dysplasia and epilepsy: an ontogenetic hypothesis based
on volumetric MRI and NeuN neuronal density and size measurements..
Cerebral cortex (New York, N.Y. : 1991).
2005;
15(2):
194-210.
Cepeda Carlos, Starling Amaal J, Wu Nanping, Nguyen Oanh K, Uzgil Besim, Soda Takahiro, André Veronique M, Ariano Marjorie A, Levine Michael S Increased GABAergic function in mouse models of Huntington's disease:
reversal by BDNF..
Journal of neuroscience research.
2004;
78(6):
855-67.
Levine Michael S, Cepeda Carlos, Hickey Miriam A, Fleming Sheila M, Chesselet Marie-Françoise Genetic mouse models of Huntington's and Parkinson's diseases:
illuminating but imperfect..
Trends in neurosciences.
2004;
27(11):
691-7.
André Véronique M, Flores-Hernández Jorge, Cepeda Carlos, Starling Amaal J, Nguyen Snow, Lobo Mary Kay, Vinters Harry V, Levine Michael S, Mathern Gary W NMDA receptor alterations in neurons from pediatric cortical dysplasia
tissue..
Cerebral cortex (New York, N.Y. : 1991).
2004;
14(6):
634-46.
Bamford Nigel S, Zhang Hui, Schmitz Yvonne, Wu Nan-Ping, Cepeda Carlos, Levine Michael S, Schmauss Claudia, Zakharenko Stanislav S, Zablow Leonard, Sulzer David Heterosynaptic dopamine neurotransmission selects sets of
corticostriatal terminals..
Neuron.
2004;
42(4):
653-63.
Hernández-Echeagaray Elizabeth, Starling Amaal J, Cepeda Carlos, Levine Michael S Modulation of AMPA currents by D2 dopamine receptors in striatal
medium-sized spiny neurons: are dendrites necessary?.
The European journal of neuroscience.
2004;
19(9):
2455-63.
Goldberg Matthew S, Fleming Sheila M, Palacino James J, Cepeda Carlos, Lam Hoa A, Bhatnagar Anushree, Meloni Edward G, Wu Nanping, Ackerson Larry C, Klapstein Gloria J, Gajendiran Mahadevan, Roth Bryan L, Chesselet Marie-Francoise, Maidment Nigel T, Levine Michael S, Shen Jie Parkin-deficient mice exhibit nigrostriatal deficits but not loss of
dopaminergic neurons..
The Journal of biological chemistry.
2003;
278(44):
43628-35.
Cepeda Carlos, Hurst Raymond S, Flores-Hernández Jorge, Hernández-Echeagaray Elizabeth, Klapstein Gloria J, Boylan Marea K, Calvert Christopher R, Jocoy Emily L, Nguyen Oanh K, André Véronique M, Vinters Harry V, Ariano Marjorie A, Levine Michael S, Mathern Gary W Morphological and electrophysiological characterization of abnormal
cell types in pediatric cortical dysplasia..
Journal of neuroscience research.
2003;
72(4):
472-86.
Flores-Hernández Jorge, Cepeda Carlos, Hernández-Echeagaray Elizabeth, Calvert Christopher R, Jokel Eve S, Fienberg Allen A, Greengard Paul, Levine Michael S Dopamine enhancement of NMDA currents in dissociated medium-sized
striatal neurons: role of D1 receptors and DARPP-32..
Journal of neurophysiology.
2002;
88(6):
3010-20.
Ariano Marjorie A, Aronin Neil, Difiglia Marian, Tagle Danilo A, Sibley David R, Leavitt Blair R, Hayden Michael R, Levine Michael S Striatal neurochemical changes in transgenic models of Huntington's
disease..
Journal of neuroscience research.
2002;
68(6):
716-29.
Hsiao Chie-Fang, Wu Nanping, Levine Michael S, Chandler Scott H Development and serotonergic modulation of NMDA bursting in rat
trigeminal motoneurons..
Journal of neurophysiology.
2002;
87(3):
1318-28.
Cepeda Carlos, Crawford Cynthia A, Margulies Jody E, Watson Joseph B, Levine Michael S, Cohen Randy W Enhanced epileptogenic susceptibility in a genetic model of reactive
synaptogenesis: the spastic Han-Wistar rat..
Developmental neuroscience.
2002;
24(4):
262-71.
Rubinstein, M Cepeda, C Hurst, RS Flores-Hernandez, J Ariano, MA Falzone, TL Kozell, LB Meshul, CK Bunzow, JR Low, MJ Levine, MS Grandy, DK Dopamine D4 receptor-deficient mice display cortical hyperexcitability..
The Journal of neuroscience : the official journal of the Society for Neuroscience. .
2001;
21(11):
3756-63.
Levine, MS Klapstein, GJ Koppel, A Gruen, E Cepeda, C Vargas, ME Jokel, ES Carpenter, EM Zanjani, H Hurst, RS Efstratiadis, A Zeitlin, S Chesselet, MF Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease..
Journal of neuroscience research. .
1999;
58(4):
515-32.
Cepeda, C Colwell, CS Itri, JN Chandler, SH Levine, MS Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances..
Journal of neurophysiology. .
1998;
79(1):
82-94.
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Our primary research interests are directed toward understanding the mechanisms underlying neuronal dysfunction in the basal ganglia and cortex in neurodegenerative disorders. The research consists of a multidisciplinary approach combining neurophysiological, morphological and molecular techniques. This research has evolved into several major projects: 1) Examining the physiological changes in mutant mouse models of Huntington's disease, 2) Assessment of neuromodulation in the striatum as in pertains to Parkinson's disease and assessment of new gentic mouse models of Parkinson's disease and 3) Examining cellular cortical electrophysiological and morphological abnormalities occurring in children suffering from intractable pediatric epilepsy. The first area of research involves using mutant murine models of Huntington's disease to understand how this neurological disorder physiologically affects cellular function. We study different types of mouse models, each with a unique part of the human Huntington's disease gene inserted into the mouse genome. We examine physiological function and morphological changes in striatal and cortical neurons, the two primary areas affected in Huntington's disease. The studies on neuromodulation have concentrated on examining interactions among receptor subtypes in the striatum and othe nuclei of the basal ganglia as well as new genetic models of Parkinson's disease. These studies emanate from our initial observations that the direction of dopamine modulation of electrophysiological responses induced by activation of excitatory amino acid receptors is dependent upon the subtypes of excitatory amino acid and dopamine receptors activated. This observation could explain many of the inconsistencies in the literature concerning the modulatory role of dopamine in the striatum and other nuclei. One of the goals of these studies is to learn the rules that guide dopaminergic modulation, to identify their mechanisms and to examine how this modulation is altered in models of Parkinson's disease to help design rational therapies for this disorder. The third area examines alterations in development of electrophysiological properties of human neocortical neurons. Pathological neocortical tissue is obtained from children suffering from pediatric epilepsy and undergoing surgery to alleviate intractable seizures. These experiments study "abnormal-appearing" neurons and they have shown that a population of neurons with altered voltage-dependent intrinsic currents and in some cases altered ligand-gated currents occurs.
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