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Faculty DataBase - FDB5

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Yi Sun, Ph.D.
   
Affiliations
Associate Professor, Psychiatry and Biobehavioral Sciences
Associate Professor In-Residence, Semel Institute for Neuroscience and Human Behavior, Molecular & Medical Pharmacology
Member, Brain Research Institute, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, Gene Regulation GPB Home Area, JCCC Gene Regulation Program Area, Molecular Pharmacology GPB Home Area, Neuroscience GPB Home Area

Education:
Degree: Ph.D.


Contact Information:
Work Email Address: ysun@mednet.ucla.edu
Psychiatry and Biobehavioral Sciences: (310) 825-9989 Information and referral (800-825-9989 from outside 310)
Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research: (310) 825-4958 Information
Laboratory Address: Laboratory
635 Charles E. Young Drive South
Los Angeles, CA 90095
UNITED STATES
Office Address: Office
NRB 351, 635 Charles E. Young Drive South
Los Angeles, CA 90095
UNITED STATES
Home Page: http://www.mrrc.npi.ucla.edu/ysun/links.htm


Direct Contact Information:
Lab Number: (310) 267-2197 Laboratory
310-267-2197 Laboratory
Office Phone Number: 310-825-9506 Office
310-825-9506 Office
Work Phone Number: 310-825-9506


Publications:
Zeng Yan, Tan Miao, Kohyama Jun, Sneddon Marissa, Watson Joseph B, Sun Yi E, Xie Cui-Wei Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(49): 17800-10.
Tao Jifang, Wu Hao, Lin Quan, Wei Weizheng, Lu Xiao-Hong, Cantle Jeffrey P, Ao Yan, Olsen Richard W, Yang X William, Mody Istvan, Sofroniew Michael V, Sun Yi E Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(22): 8306-19.
Wilburn Brian, Rudnicki Dobrila D, Zhao Jing, Weitz Tara Murphy, Cheng Yin, Gu Xiaofeng, Greiner Erin, Park Chang Sin, Wang Nan, Sopher Bryce L, La Spada Albert R, Osmand Alex, Margolis Russell L, Sun Yi E, Yang X William An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice.. Neuron. 2011; 70(3): 427-40.
Wu Hao, D'Alessio Ana C, Ito Shinsuke, Xia Kai, Wang Zhibin, Cui Kairong, Zhao Keji, Sun Yi Eve, Zhang Yi Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.. Nature. 2011; 473(7347): 389-93.
Wu Hao, D'Alessio Ana C, Ito Shinsuke, Wang Zhibin, Cui Kairong, Zhao Keji, Sun Yi Eve, Zhang Yi Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.. Genes & development. 2011; 25(7): 679-84.
Ge, W He, F Kim, KJ Blanchi, B Coskun, V Nguyen, L Wu, X Zhao, J Heng, JI Martinowich, K Tao, J Wu, H Castro, D Sobeih, MM Corfas, G Gleeson, JG Greenberg, ME Guillemot, F Sun, YE Coupling of cell migration with neurogenesis by proneural bHLH factors.. PNAS. 2006; 103(5): 1319-1324.
Damelin, M Sun, YE Sodja, VB Bestor, TH Decatenation checkpoint deficiency in stem and progenitor cells.. Cancer cell.. 2005; 8(6): 479-84.
Ladi, E Nichols, JT Ge, W Miyamoto, A Yao, C Yang, LT Boulter, J Sun, YE Kintner, C Weinmaster, G The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands.. The Journal of cell biology. . 2005; 170(6): 983-92.
Fan, G Martinowich, K Chin, MH He, F Fouse, SD Hutnick, L Hattori, D Ge, W Shen, Y Wu, H ten Hoeve, J Shuai, K Sun, YE DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.. Development (Cambridge, England) . 2005; 132(15): 3345-56.
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He, F Ge, W Martinowich, K Becker-Catania, S Coskun, V Zhu, W Wu, H Castro, D Guillemot, F Fan, G de Vellis, J Sun, YE A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis.. Nature neuroscience. . 2005; 8(5): 616-25.
Martin, KC Sun, YE To learn better, keep the HAT on.. Neuron. . 2004; 42(6): 879-81.
Martinowich, K Hattori, D Wu, H Fouse, S He, F Hu, Y Fan, G Sun, YE DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.. Science. . 2003; 302(5646): 890-3.
Sun, Y Nadal-Vicens, M Misono, S Lin, MZ Zubiaga, A Hua, X Fan, G Greenberg, ME Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.. Cell. . 2001; 104(3): 365-76.
Fan G, Egles C, Sun Y, Minichiello L, Renger J, Klein R, Liu G, Jaenisch R NT4 and BDNF have Overlapping as well as Distinct Function in vivo. Nature Neuroscience 2000; 3: 350-357.
Gao, Y Sun, Y Frank, KM Dikkes, P Fujiwara, Y Seidl, KJ Sekiguchi, JM Rathbun, GA Swat, W Wang, J Bronson, RT Malynn, BA Bryans, M Zhu, C Chaudhuri, J Davidson, L Ferrini, R Stamato, T Orkin, SH Greenberg, ME Alt, FW A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.. Cell. . 1998; 95(7): 891-902.
Bonni A*, Sun Y*(equal first authorship), Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME Regulation of CNS Gliogenesis by JAK-STAT Signaling Pathway. Science 1997; 278: 477-483.
Rao MS, Sun Y, Escary JL, Perreau J, Tresser S, Patterson PH, Zigmond RE, Brulet P, Landis SC Leukemia Inhibitory Factor Mediates an Injury Response but not a target-directed developmental transmitter switch in sympathetic neurons. Neuron 1993; 11: 1175-1185.