Karen Gylys, Ph.D.


Work Titles and Affiliation
UCLA Professor, School of Nursing
Education:
Degrees:
Ph.D.

Contact Information:

Email Address:

kgylys@sonnet.ucla.edu


Lab Number:

310 794-5472

Office Phone Number:

310-206-3840

Work Address:

Office
Factor Building 6-266
Los Angeles, CA 90095

Detailed Biography:

Karen Hoppens Gylys is a neuroscientist who joined the faculty of the School of Nursing and the Brain Research Institute in 1998. Dr. Gylys earned a B.S. degree in Nursing and a M.S. degree in Human Development at the University of Texas, Dallas. She received her Ph.D. in Neuroscience, with a major in neuropharmacology, at UCLA in 1993, and did postdoctoral work on molecular mechanisms of opioid tolereance in the NPI. Since joining the faculty of the School of Nursing, she has taught pharmacology and research in the School of Nursing and is actively involved in the BRI. Her laboratory research is focused on understanding the dysfunction and loss of synapses that occurs in Alzheimer's disease, which is thought to underlie the earliest cognitive impairments.

Publications:

Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Miller Carol A, Vinters Harry V, Poon Wayne, Cole Gregory M, Gylys Karen Hoppens   AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly Neurobiology of aging, 2012; 33(8): 1545-55.
Arold Stephen, Sullivan Patrick, Bilousova Tina, Teng Edmond, Miller Carol A, Poon Wayne W, Vinters Harry V, Cornwell Lindsey B, Saing Tommy, Cole Gregory M, Gylys Karen Hoppens   Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex Acta neuropathologica, 2012; 123(1): 39-52.
Ringman John M, Coppola Giovanni, Elashoff David, Rodriguez-Agudelo Yaneth, Medina Luis D, Gylys Karen, Cummings Jeffrey L, Cole Greg M   Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease Dementia and geriatric cognitive disorders, 2012; 33(1): 1-5.
Ringman John M, Tomic Jennifer L, Coppola Giovanni, Elashoff David, Gylys Karen H, Glabe Charles G   Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers Dementia and geriatric cognitive disorders extra, 2012; 2(1): 652-7.
Henkins Kristen M, Sokolow Sophie, Miller Carol A, Vinters Harry V, Poon Wayne W, Cornwell Lindsey B, Saing Tommy, Gylys Karen Hoppens   Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses Brain pathology (Zurich, Switzerland), 2012; 22(6): 826-33.
Sokolow Sophie, Henkins Kristen M, Williams Iris A, Vinters Harry V, Schmid Ingrid, Cole Gregory M, Gylys Karen H   Isolation of synaptic terminals from Alzheimer's disease cortex Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2012; 81(3): 248-54.
Ringman John M, Frautschy Sally A, Teng Edmond, Begum Aynun N, Bardens Jenny, Beigi Maryam, Gylys Karen H, Badmaev Vladimir, Heath Dennis D, Apostolova Liana G, Porter Verna, Vanek Zeba, Marshall Gad A, Hellemann Gerhard, Sugar Catherine, Masterman Donna L, Montine Thomas J, Cummings Jeffrey L, Cole Greg M   Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study Alzheimer's research & therapy, 2012; 4(5): 43.
Ringman John M, Elashoff David, Geschwind Daniel H, Welsh Brian T, Gylys Karen H, Lee Cathy, Cummings Jeffrey L, Cole Greg M   Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype Archives of neurology, 2012; 69(6): 757-64.
Sokolow Sophie, Luu Sanh H, Nandy Karabi, Miller Carol A, Vinters Harry V, Poon Wayne W, Gylys Karen H   Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex Neurobiology of disease, 2012; 45(1): 381-7.
Ringman John M, Schulman Howard, Becker Chris, Jones Ted, Bai Yuchen, Immermann Fred, Cole Gregory, Sokolow Sophie, Gylys Karen, Geschwind Daniel H, Cummings Jeffrey L, Wan Hong I   Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations Archives of neurology, 2012; 69(1): 96-104.
Ringman John M, Gylys Karen H, Medina Luis D, Fox Michelle, Kepe Vladimir, Flores Deborah L, Apostolova Liana G, Barrio Jorge R, Small Gary, Silverman Daniel H, Siu Erin, Cederbaum Stephen, Hecimovic Silva, Malnar Martina, Chakraverty Suma, Goate Alison M, Bird Thomas D, Leverenz James B   Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation Neuroscience letters, 2011; 487(3): 287-92.
Sokolow Sophie, Luu Sanh H, Headley Alison J, Hanson Alecia Y, Kim Taeree, Miller Carol A, Vinters Harry V, Gylys Karen H   High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease Cell calcium, 2011; 49(4): 208-16.
10. Sokolow S, Henkins KM, Bilousova , Williams IA, Vinters HV, Cole GM, Schmid I, Gylys KH.   Isolation of synaptic terminals from Alzheimer’s disease cortex, Brain Pathology, 2012; 81((3)): 248-254.
Tai Leon M, Bilousova Tina, Jungbauer Lisa, Roeske Stephen K, Youmans Katherine L, Yu Chunjiang, Poon Wayne W, Cornwell Lindsey B, Miller Carol A, Vinters Harry V, Van Eldik Linda J, Fardo David W, Estus Steve, Bu Guojun, Gylys Karen Hoppens, Ladu Mary Jo   Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples The Journal of biological chemistry, 2013; 288(8): 5914-26.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Gonzalez Bianca, Vinters Harry V, Miller Carol A, Cornwell Lindsey, Poon Wayne W, Gylys Karen H   Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease Journal of neurochemistry, 2015; 133(3): 368-79.
Ringman John M, Fithian Andrew T, Gylys Karen, Cummings Jeffrey L, Coppola Giovanni, Elashoff David, Pratico Domenico, Moskovitz Jackob, Bitan Gal   Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations Dementia and geriatric cognitive disorders, 2012; 33(4): 219-25.

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MeSH Vocabulary includes four types of terms:

  • Headings
  • Subheadings
  • Supplementary Concept Records
  • Publication Characteristics (or Types)

Over 26,000 MeSH headings (also called "main headings" or "descriptors" represents concepts found in the biomedical literature

Subheadings - (also called qualifiers) are attached to MeSH headings to describe a specific aspect of a concept.

Supplementary Concept Records are over 200,000 terms in a separate thesaurus from the Medical Subject Headings. These are primarily substance terms, but also include some protocols and rare desease terms. These terms are updated weekly.

Publication Characteristics or (Publication Types) describe the type of publication being indexed; i.e., what the item is, not what the article is about.

Information from U.S. National Library of Medicine.

Affect Aged Alleles Alzheimer Disease Amyloid Amyloid beta-Peptides Animals Apolipoprotein E4 Apolipoproteins E Autopsy Biological Assay Brain Cerebellum Cholesterol Congo Red Disease Drug Delivery Systems Entorhinal Cortex Flow Cytometry Focal Adhesions Frontal Lobe Genotype Gliosis Goals Humans Integrins Laboratories Light Lipids Membrane Microdomains Methods Mice Mice, Transgenic Molecular Conformation Neuroglia Parietal Lobe Pathology Peptides Pharmaceutical Preparations Phosphoric Monoester Hydrolases Phosphotransferases Presynaptic Terminals Protein Isoforms Proteins Proteomics Role Seeds Signal Transduction Synapses Synaptosomes Tissues Work tau Proteins

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