UCLA Neuroscience Program Ph.D. Admissions Neuroscience Faculty UCLA and Beyond  



Rhonda Voskuhl
Neuroimmunology, Neuroendocrinology and Neuroprotection

Email Address:  rvoskuhl@ucla.edu
Home Page: http://faculty.bri.ucla.edu/institution/personnel?personnel_id=9327 Home Page: http://www.uclahealth.org/RhondaVoskuhl Group Home Page Redirect: http://www.neurology.ucla.edu/research.jsp?m=4&s=1_10 Group Home Page Redirect: http://www.neurology.ucla.edu/clinical.jsp?m=2&s=4_7 Group Home Page Redirect: http://www.clinicaltrials.gov/ct2/show/NCT00451204?term=estriol+multiple+sclerosis&rank=1

Office Address:
635 Charles E. Young Drive South


Phone Numbers:
(310) 206-4636 work


Selected Publications:

Voskuhl, R. R. Palaszynski, K. Sex hormones and experimental autoimmune encephalomyelitis:Implications for multiple sclerosis. The Neuroscientist 2001; 7(3): 258-270.
Liva, S.M. Voskuhl, R.R. Testosterone acts directly on CD4+ T-lymphocytes to increase IL10 production. Journal of Immunology 2001; 167: 2060-2067.
Tiwari-Woodruff Seema, Morales Laurie Beth J, Lee Ruri, Voskuhl Rhonda R Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(37): 14813-8.
Sicotte Nancy L, Giesser Barbara S, Tandon Vinita, Klutch Ricki, Steiner Barbara, Drain Ann E, Shattuck David W, Hull Laura, Wang He-Jing, Elashoff Robert M, Swerdloff Ronald S, Voskuhl Rhonda R Testosterone treatment in multiple sclerosis: a pilot study. Archives of neurology. 2007; 64(5): 683-8.
Ziehn Marina O, Avedisian Andrea A, Dervin Shannon M, Umeda Elizabeth A, O'Dell Thomas J, Voskuhl Rhonda R Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in the Hippocampus during Autoimmune Demyelinating Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012; 32(36): 12312-24.
MacKenzie-Graham Allan, Tinsley Matthew R, Shah Kaanan P, Aguilar Cynthia, Strickland Lauren V, Boline Jyl, Martin Melanie, Morales Laurie, Shattuck David W, Jacobs Russell E, Voskuhl Rhonda R, Toga Arthur W Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. NeuroImage. 2006; 32(3): 1016-23.
Smith Deborah L, Dong Xin, Du Sienmi, Oh Myungshin, Singh Ram Raj, Voskuhl Rhonda R A female preponderance for chemically induced lupus in SJL/J mice. Clinical immunology (Orlando, Fla.). 2007; 122(1): 101-7.
Sasidhar Manda V, Itoh Noriko, Gold Stefan M, Lawson Gregory W, Voskuhl Rhonda R The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY. Annals of the rheumatic diseases. 2012; 71(8): 1418-22.
Gold Stefan M, Voskuhl Rhonda R Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders. Current opinion in investigational drugs (London, England : 2000). 2006; 7(7): 625-30.
Gold Stefan M, Sasidhar Manda V, Lagishetty Venu, Spence Rory D, Umeda Elizabeth, Ziehn Marina O, Krieger Thorsten, Schulz Karl-Heinz, Heesen Christoph, Hewison Martin, Voskuhl Rhonda R Dynamic Development of Glucocorticoid Resistance during Autoimmune Neuroinflammation. The Journal of clinical endocrinology and metabolism. 2012; 97(8): E1402-10.
Morales Laurie Beth J, Loo Kyi Kyi, Liu Hong-Biao, Peterson Cory, Tiwari-Woodruff Seema, Voskuhl Rhonda R Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006; 26(25): 6823-33.
Ziehn Marina O, Avedisian Andrea A, Dervin Shannon M, O'Dell Thomas J, Voskuhl Rhonda R Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease. Laboratory investigation; a journal of technical methods and pathology. 2012; 92(8): 1234-45.
Palaszynski Karen M, Smith Deborah L, Kamrava Shana, Burgoyne Paul S, Arnold Arthur P, Voskuhl Rhonda R A yin-yang effect between sex chromosome complement and sex hormones on the immune response. Endocrinology. 2005; 146(8): 3280-5.
MacKenzie-Graham Allan J, Rinek Gilda A, Avedisian Andrea, Morales Laurie B, Umeda Elizabeth, Boulat Benoit, Jacobs Russell E, Toga Arthur W, Voskuhl Rhonda R Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis. Journal of neuroscience research. 2012; 90(7): 1310-23.
Voskuhl Rhonda R, Gold Stefan M Sex-related factors in multiple sclerosis susceptibility and progression. Nature reviews. Neurology. 2012; 8(5): 255-63.
Daumer Martin, Weinshenker Brian G, Voskuhl Rhonda Pregnancy: a "modifiable" risk factor in MS?. Neurology. 2012; 78(12): 846-8.
Soldan Samantha S, Alvarez Retuerto Ana Isabel, Sicotte Nancy L, Voskuhl Rhonda R Dysregulation of IL-10 and IL-12p40 in secondary progressive multiple sclerosis. Journal of neuroimmunology. 2004; 146(1-2): 209-15.
MacKenzie-Graham Allan, Rinek Gilda A, Avedisian Andrea, Gold Stefan M, Frew Andrew J, Aguilar Cynthia, Lin David R, Umeda Elizabeth, Voskuhl Rhonda R, Alger Jeffry R Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. NeuroImage. 2012; 60(1): 95-104.
Spence Rory D, Voskuhl Rhonda R Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration. Frontiers in neuroendocrinology. 2012; 33(1): 105-15.
Spence Rory D, Hamby Mary E, Umeda Elizabeth, Itoh Noriko, Du Sienmi, Wisdom Amy J, Cao Yuan, Bondar Galyna, Lam Jeannie, Ao Yan, Sandoval Francisco, Suriany Silvie, Sofroniew Michael V, Voskuhl Rhonda R Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(21): 8867-72.
Liu Hong-biao, Loo Kyi Kyi, Palaszynski Karen, Ashouri Judith, Lubahn Dennis B, Voskuhl Rhonda R Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. Journal of immunology (Baltimore, Md. : 1950). 2003; 171(12): 6936-40.
Soldan Samantha S, Alvarez Retuerto Ana Isabel, Sicotte Nancy L, Voskuhl Rhonda R Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. Journal of immunology (Baltimore, Md. : 1950). 2003; 171(11): 6267-74.
Voskuhl Rhonda Sex differences in autoimmune diseases. Biology of sex differences. 2011; 2(1): 1.
Du Sienmi, Sandoval Francisco, Trinh Pauline, Umeda Elizabeth, Voskuhl Rhonda Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease. European journal of immunology. 2011; 41(1): 140-50.
Sicotte Nancy L, Liva Stephanie M, Klutch Rochelle, Pfeiffer Paul, Bouvier Seth, Odesa Sylvia, Wu T C Jackson, Voskuhl Rhonda R Treatment of multiple sclerosis with the pregnancy hormone estriol. Annals of neurology. 2002; 52(4): 421-8.
Crawford Daniel K, Mangiardi Mario, Song Bingbing, Patel Rhusheet, Du Sienmi, Sofroniew Michael V, Voskuhl Rhonda R, Tiwari-Woodruff Seema K Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain : a journal of neurology. 2010; 133(10): 2999-3016.
Ziehn Marina O, Avedisian Andrea A, Tiwari-Woodruff Seema, Voskuhl Rhonda R Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE. Laboratory investigation; a journal of technical methods and pathology. 2010; 90(5): 774-86.
Du Sienmi, Sandoval Francisco, Trinh Pauline, Voskuhl Rhonda R Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis. Journal of neuroimmunology. 2010; 219(1-2): 64-74.
Voskuhl Rhonda R, Pribyl Thomas M, Kampf Kathy, Handley Vance, Liu Hong-biao, Feng JiMing, Campagnoni Celia W, Soldan Samantha S, Messing Albee, Campagnoni Anthony T Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice. Journal of neuroimmunology. 2003; 139(1-2): 44-50.
Liu Hongbiao, Ding Yi, Voskuhl Rhonda R Method to detect functional estrogen receptor expression using estrogen receptor probing compound. Journal of immunoassay & immunochemistry. 2005; 26(4): 295-301.
Voskuhl Rhonda R Gender issues and multiple sclerosis. Current neurology and neuroscience reports. 2002; 2(3): 277-86.
Palaszynski Karen M, Liu Hongbiao, Loo Kyi Kyi, Voskuhl Rhonda R Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Journal of neuroimmunology. 2004; 149(1-2): 84-9.
Wisdom Amy J, Cao Yuan, Itoh Noriko, Spence Rory D, Voskuhl Rhonda R Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model. Journal of neuroscience research. 2013; 91(7): 901-8.
Palaszynski Karen M, Loo Kyi Kyi, Ashouri Judith F, Liu Hong-biao, Voskuhl Rhonda R Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Journal of neuroimmunology. 2004; 146(1-2): 144-52.
Voskuhl Rhonda R Assisted reproduction technology in multiple sclerosis: giving birth to a new avenue of research in hormones and autoimmunity. Annals of neurology. 2012; 72(5): 631-2.
Sicotte Nancy L, Voskuhl Rhonda R, Bouvier Seth, Klutch Rochelle, Cohen Mark S, Mazziotta John C Comparison of multiple sclerosis lesions at 1.5 and 3.0 Tesla. Investigative radiology. 2003; 38(7): 423-7.
Mangiardi Mario, Crawford Daniel K, Xia Xiaoyu, Du Sienmi, Simon-Freeman Rebecca, Voskuhl Rhonda R, Tiwari-Woodruff Seema K An animal model of cortical and callosal pathology in multiple sclerosis. Brain pathology (Zurich, Switzerland). 2011; 21(3): 263-78.
Research Interest:

The Voskuhl laboratory is focused on understanding mechanisms in central nervous system inflammation and neurodegeneration. The disease of interest is multiple sclerosis, but other diseases as well that have inflammatory or neurodegenerative components are studied. The goal of the lab is to find novel anti-inflammatory and neuroprotective agents to halt these mechanisms. Thus far, two different agents have each reached clinical trials in MS patients based on basic research done in the Voskuhl lab.